@article {CouraudERJ-00973-2014, author = {S{\'e}bastien Couraud and Didier Debieuvre and Lionel Moreau and Patrick Dumont and Jacques Margery and Elisabeth Quoix and Bernard Duvert and Laurent Cellerin and Nathalie Baize and Bruno Taviot and Marie Coudurier and Jacques Cadranel and Pascale Missy and Franck Morin and Jean-Fran{\c c}ois Mornex and G{\'e}rard Zalcman and Pierre-Jean Souquet}, title = {No impact of passive smoke on the somatic profile of lung cancers in never-smokers}, elocation-id = {ERJ-00973-2014}, year = {2015}, doi = {10.1183/09031936.00097314}, publisher = {European Respiratory Society}, abstract = {EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a {\textquotedblleft}smoker-like{\textquotedblright} somatic profile compared with unexposed never-smokers. Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled. Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66\%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation: 46\% in never exposed versus 41\% in ever exposed; KRAS: 7\% versus 7\%; ALK: 13\% versus 11\%; HER2: 4\% versus 5\%; BRAF: 6\% versus 5\%; PIK3CA: 4\% versus 2\%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers. There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer. Never-smokers with lung cancer exposed to passive smoke do not have a smoker-like somatic mutation profile http://ow.ly/Eheoi}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/early/2015/03/09/09031936.00097314}, eprint = {https://erj.ersjournals.com/content/early/2015/03/09/09031936.00097314.full.pdf}, journal = {European Respiratory Journal} }