TY - JOUR T1 - Impaired lung function is associated with systemic inflammation and macrophage activation JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00187514 SP - ERJ-01875-2014 AU - Katherine J. Baines AU - Vibeke Backer AU - Peter G. Gibson AU - Heather Powel AU - Celeste M. Porsbjerg Y1 - 2014/12/10 UR - http://erj.ersjournals.com/content/early/2014/12/16/09031936.00187514.abstract N2 - Lung function impairment, as assessed by a reduction in the forced expiratory volume measured in the first second of exhalation (FEV1) and forced vital capacity (FVC), contributes significantly to several major health issues, such as all-cause mortality [1, 2], chronic lung disease prevalence (chronic obstructive pulmonary disease (COPD) and asthma) [3, 4], and death from cardiovascular disease [5]. Preservation of lung health during ageing [6] through identification of modifiable risk factors is a key research priority. Systemic inflammation and macrophage activation play a role in modulating lung function http://ow.ly/DAgFI The authors would like to acknowledge the technical assistance of Heather Macdonald and Michelle Gleeson (Priority Research Centre for Asthma and Respiratory Disease, University of Newcastle, Newcastle, Australia). The authors would also like to acknowledge Peter Bjerregaard (National Institute of Public Health, University of Southern Denmark, Odense, Denmark) and the Greenlandic Population Study. This study was funded by the Bispebjerg University Hospital. ER -