TY - JOUR T1 - Effects of antenatal multiple micronutrient supplementation on lung function in mid-childhood: follow-up of a double-blind randomised controlled trial in Nepal JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00188914 SP - ERJ-01889-2014 AU - Delan Devakumar AU - Janet Stocks AU - Jon G. Ayres AU - Jane Kirkby AU - Sushil K. Yadav AU - Naomi M. Saville AU - Graham Devereux AU - Jonathan C.K. Wells AU - Dharma S. Manandhar AU - Anthony Costello AU - David Osrin Y1 - 2015/02/19 UR - http://erj.ersjournals.com/content/early/2015/02/19/09031936.00188914.abstract N2 - A randomised trial of prenatal multiple micronutrient supplementation in Nepalese women increased birthweight and weight at 2 years of age in offspring, compared to those born to mothers who only received iron and folic acid supplements. Further follow-up of this cohort provided an opportunity to investigate the effect of antenatal multiple micronutrients on subsequent lung function by measuring spirometry at 7–9 years of age in children born during the trial. 841 children (80% of the cohort) were seen at mean±sd 8.5±0.4 years. Technically successful spirometry results were obtained in 793 (94.3%) children, 50% of whom had been randomised to micronutrient supplementation. Background characteristics, including anthropometry, were similar in the two allocation groups. Lung function was also similar, mean (95% CI) difference in z-scores (supplementation minus control) was −0.08 (−0.19–0.04), −0.05 (−0.17–0.06) and −0.04 (−0.15–0.07) for forced expiratory volume in 1 s (FEV1), forced vital capacity and FEV1/FVC, respectively. Compared with healthy white children, FEV1 and FVC in the “healthy” Nepalese children were ∼1 (∼13%) z-score lower, with no difference in FEV1/FVC. We conclude that, compared with routine iron and folic acid, multiple micronutrient supplementation during pregnancy has no effect on spirometric lung function in Nepalese children at 8.5 years of age. Prenatal multiple micronutrient supplements do not improve spirometric lung function at 8 years in Nepalese children http://ow.ly/HKBsK ER -