PT  - JOURNAL ARTICLE
AU  - Nicholas T. Vozoris
AU  - Hadas D. Fischer
AU  - Xuesong Wang
AU  - Anne L. Stephenson
AU  - Andrea S. Gershon
AU  - Andrea Gruneir
AU  - Peter C. Austin
AU  - Geoffrey M. Anderson
AU  - Chaim M. Bell
AU  - Sudeep S. Gill
AU  - Paula A. Rochon
TI  - Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD
AID  - 10.1183/09031936.00008014
DP  - 2014 Apr 17
TA  - European Respiratory Journal
PG  - erj00080-2014
4099  - http://erj.ersjournals.com/content/early/2014/04/16/09031936.00008014.short
4100  - http://erj.ersjournals.com/content/early/2014/04/16/09031936.00008014.full
AB  - Our purpose was to evaluate the association of new benzodiazepine use relative to non-use with adverse clinical respiratory outcomes among older adults with chronic obstructive pulmonary disease (COPD). This was a retrospective population-based cohort study of Ontario, Canada, residents between 2003 and 2010. A validated algorithm was applied to health administrative data to identify adults aged 66 years and older with COPD. Relative risks (RRs) of several clinically important respiratory outcomes were examined within 30 days of incident benzodiazepine use compared with non-use, applying propensity score matching. New benzodiazepine users were at significantly higher risk for outpatient respiratory exacerbations (RR 1.45, 95% CI 1.36–1.54) and emergency room visits for COPD or pneumonia (RR 1.92, 95% CI 1.69–2.18) compared to non-users. Risk of hospitalisation for COPD or pneumonia was also increased in benzodiazepine users, but was nonsignificant (RR 1.09, 95% CI 1.00–1.20). There were no significant differences in intensive care unit admissions between the two groups and all-cause mortality was slightly lower among new versus non-users. Benzodiazepines were associated with increased risk for several serious adverse respiratory outcomes among older adults with COPD. The findings suggest that decisions to use benzodiazepines in older patients with COPD need to consider potential adverse respiratory outcomes. Benzodiazepines are associated with increased risk of adverse respiratory outcomes among older adults with COPD http://ow.ly/uTScu