@article {Puhanerj01316-2012, author = {Milo A. Puhan and Lara Siebeling and Marco Zoller and Patrick Muggensturm and Gerben ter Riet}, title = {Simple functional performance tests and mortality in COPD}, elocation-id = {erj01316-2012}, year = {2013}, doi = {10.1183/09031936.00131612}, publisher = {European Respiratory Society}, abstract = {Exercise tests are important to characterize COPD patients and predict their prognosis but often not available outside of rehabilitation or research settings. The aim was to assess the predictive performance of the sit-to-stand (STS) and handgrip strength tests.The prospective cohort study in Dutch and Swiss primary care settings included a broad spectrum of patients (n=409) with GOLD stages II to IV. To assess the association of the tests with outcomes, we used Cox proportional hazards (mortality), negative binomial (centrally adjudicated exacerbations) and mixed linear regression models (longitudinal health-related quality of life [HRQL]) while adjusting for age, sex and severity of disease.The STS test was strongly (adjusted hazard ratio per 5 more repetitions of 0.58 [95\% CI 0.40{\textendash}0.85], p=0.004) and the handgrip strength test moderately strongly (0.84 [95\% CI 0.72{\textendash}1.00], p=0.04) associated with mortality. Both tests were also statistically significantly associated with HRQL but not with exacerbations. The STS test alone was a stronger predictor of 2-year mortality (area under curve 0.78) than body mass index (0.52), FEV1 (0.61), dyspnoea (0.63) and handgrip strength (0.62).The STS test may close an important gap in the evaluation of exercise capacity and prognosis of COPD patients across practice settings.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/early/2013/03/20/09031936.00131612}, eprint = {https://erj.ersjournals.com/content/early/2013/03/20/09031936.00131612.full.pdf}, journal = {European Respiratory Journal} }