RT Journal Article SR Electronic T1 Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP erj00424-2014 DO 10.1183/09031936.00042414 A1 Nadzeya V. Marozkina A1 Xin-Qun Wang A1 Vitali Stsiapura A1 Anne Fitzpatrick A1 Silvia Carraro A1 Gregory A. Hawkins A1 Eugene Bleecker A1 Deborah Meyers A1 Nizar Jarjour A1 Sean B. Fain A1 Sally Wenzel A1 William Busse A1 Mario Castro A1 Reynold A. Panettieri, Jr A1 Wendy Moore A1 Stephen J. Lewis A1 Lisa A. Palmer A1 Talissa Altes A1 Eduard E. de Lange A1 Serpil Erzurum A1 W. Gerald Teague A1 Benjamin Gaston YR 2014 UL http://erj.ersjournals.com/content/early/2014/10/30/09031936.00042414.abstract AB S-nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S-nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients. We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in the Severe Asthma Research Program. We also analysed phenotype and genotype data taken from the program as a whole. Airway S-nitrosoglutathione reductase activity was increased in asthma patients (p = 0.032). However, only a subpopulation was affected and this subpopulation was not defined by a “severe asthma” diagnosis. Subjects with increased activity were younger, had higher IgE and an earlier onset of symptoms. Consistent with a link between S-nitrosoglutathione biochemistry and atopy: 1) interleukin 13 increased S-nitrosoglutathione reductase expression and 2) subjects with an S-nitrosoglutathione reductase single nucleotide polymorphism previously associated with asthma had higher IgE than those without this single nucleotide polymorphism. Expression was higher in airway epithelium than in smooth muscle and was increased in regions of the asthmatic lung with decreased airflow. An early-onset, allergic phenotype characterises the asthma population with increased S-nitrosoglutathione reductase activity. Asthma patients with increased S-nitrosoglutathione reductase activity have early-onset asthma + are highly allergic http://ow.ly/AuJ9z