TY - JOUR T1 - Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00017114 SP - erj00171-2014 AU - María Torres-Durán AU - Alberto Ruano-Ravina AU - Isaura Parente-Lamelas AU - Virginia Leiro-Fernández AU - José Abal-Arca AU - Carmen Montero-Martínez AU - Carolina Pena-Álvarez AU - Francisco Javier González-Barcala AU - Olalla Castro-Añón AU - Antonio Golpe-Gómez AU - Cristina Martínez AU - María José Mejuto-Martí AU - Alberto Fernández-Villar AU - Juan Miguel Barros-Dios Y1 - 2014/01/01 UR - http://erj.ersjournals.com/content/early/2014/07/17/09031936.00017114.abstract N2 - The aim of the study was to assess the effect of residential radon exposure on the risk of lung cancer in never-smokers and to ascertain if environmental tobacco smoke modifies the effect of residential radon. We designed a multicentre hospital-based case-control study in a radon-prone area (Galicia, Spain). All participants were never-smokers. Cases had an anatomopathologically confirmed primary lung cancer and controls were recruited from individuals undergoing minor, non-oncological surgery. Residential radon was measured using alpha track detectors. We included 521 individuals, 192 cases and 329 controls, 21% were males. We observed an odds ratio (95% CI) of 2.42 (1.45–4.06) for individuals exposed to ≥200 Bq·m−3 compared with those exposed to <100 Bq·m−3. Environmental tobacco smoke exposure at home increased lung cancer risk in individuals with radon exposure >200 Bq·m−3. Individuals exposed to environmental tobacco smoke and to radon concentrations >200 Bq·m−3 had higher lung cancer risk than those exposed to lower radon concentrations and exposed to environmental tobacco smoke. Residential radon increases lung cancer risk in never-smokers. An association between residential radon exposure and environmental tobacco smoke on the risk of lung cancer might exist. Residential radon exposure increases risk of lung cancer in never-smokers, ETS exposure may raise radon effect http://ow.ly/xRVte ER -