RT Journal Article
SR Electronic
T1 Exercise training reverses exertional oscillatory ventilation in heart failure patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01670-2011
DO 10.1183/09031936.00167011
A1 Marzena Zurek
A1 Ugo Corrà
A1 Massimo F. Piepoli
A1 Ronald K. Binder
A1 Hugo Saner
A1 Jean-Paul Schmid
YR 2012
UL http://erj.ersjournals.com/content/early/2012/03/08/09031936.00167011.abstract
AB Exertional oscillatory ventilation (EOV) is an ominous prognostic sign in chronic heart failure (CHF), but little is known about the success of specific therapeutic interventions.To study the impact of an exercise training on exercise capacity and cardiopulmonary adaptation in stable CHF patients with left ventricular systolic dysfunction and EOV.96 stable CHF patients with EOV were included in a retrospective analysis (52 training vs. 44 controls). EOV was defined as follows: (1) ≥3 oscillatory fluctuations in VE during exercise; (2) regular oscillations; (3) minimal average ventilation amplitude ≥5 litres.EOV disappeared in 37/52 (71.2%) patients after training but only in 1/44 (2.3%) without training (p<0.001). The decrease of EOV amplitude correlated with changes in PETCO2 (r= -0.60, p<0.001) at the respiratory compensation point (RCP) and VE/VCO2 slope (r=0.50, p<0.001). Training significantly improved resting values of breathing frequency (BF), ventilation (VE), tidal volume (VT) and VE/VCO2 ratio. During exercise, VE and VT reached significantly higher values at the peak, while BF and VE/VCO2 ratio were significantly lower at submaximal exercise. No change was noted in the control group.Exercise training leads to a significant decrease of EOV and improves ventilatory efficiency in patients with stable CHF.