PT  - JOURNAL ARTICLE
AU  - Herth, Felix J.F.
AU  - Eberhardt, Ralf
AU  - Gompelmann, Daniela
AU  - Ficker, Joachim H.
AU  - Wagner, Manfred
AU  - Ek, Lars
AU  - Schmidt, Bernd
AU  - Slebos, Dirk-Jan
TI  - Radiological and clinical outcomes of using chartis to plan endobronchial valve treatment
AID  - 10.1183/09031936.00015312
DP  - 2012 Jan 01
TA  - European Respiratory Journal
PG  - erj00153-2012
4099  - http://erj.ersjournals.com/content/early/2012/05/02/09031936.00015312.short
4100  - http://erj.ersjournals.com/content/early/2012/05/02/09031936.00015312.full
AB  - One-way endobronchial valves (EBV) have been shown to relieve symptoms of emphysema, particularly in patients without collateral ventilation (CV) between the target and adjacent lobes. In this study, we investigated the ability of the bronchoscopic Chartis Pulmonary Assessment SystemTM to predict treatment response by determining the presence of CV.EBV patients (n=80) underwent a pre-treatment Chartis assessment. Before and 30 days after implantation, high-resolution CT scans were taken to determine target lobe volume reduction (TLVR). A pre- to post-treatment reduction of ≥350 mL was defined as significant. In addition, clinical outcomes (FEV1, 6-minute walk test and SGRQ) were compared over the same time period.Of the 51 patients classified as having an absence of CV according to their Chartis reading, 36 showed a TLVR ≥350 mL. Twenty-nine patients were classified as having CV, and of these 24 did not meet this TLVR cut-off. Chartis showed an accuracy level of 75% in predicting whether or not the TLVR cut-off would be reached. Those predicted to respond showed significantly greater TLVR (p < 0.0001) and FEV1 improvement (p=0.0013) than those predicted not to respond.Chartis is a safe and effective method of predicting response to EBV treatment.