PT  - JOURNAL ARTICLE
AU  - Megan E Jensen
AU  - Peter G Gibson
AU  - Clare E Collins
AU  - Lisa G Wood
TI  - Airway and systemic inflammation in obese children with asthma
AID  - 10.1183/09031936.00124912
DP  - 2013 Jan 01
TA  - European Respiratory Journal
PG  - erj01249-2012
4099  - http://erj.ersjournals.com/content/early/2013/01/23/09031936.00124912.short
4100  - http://erj.ersjournals.com/content/early/2013/01/23/09031936.00124912.full
AB  - Obese asthma presents via altered airway and systemic inflammation in adults. This has not been comprehensively described in children.To compare airway and systemic inflammation in obese and non-obese asthmatic children and controls.In a cross-sectional study, children aged 8–17 yr were assigned to one of four groups: obese asthma (OA, n=74); non-obese asthma (NOA, n=249); obese control (OC, n=9); non-obese control (NOC, n=29). Lung function, and both sputum and systemic inflammatory biomarkers were measured.Non-eosinophilic asthma was more prevalent among OA females (60.0%) versus OA males (30.8%). However, there were no differences in %eosinophils or %neutrophils between OA and NOA. Leptin was higher in OC, but not OA, versus NOA and NOC, while adiponectin was reduced in OA versus NOC only. Expiratory reserve volume was reduced in OA, versus NOC. Residual volume (RV) and RV/total lung capacity were reduced in OC versus OA, and OC versus OA and NOA, respectively.Obesity was associated with significant lung restriction in children with and without asthma. Obesity was not associated with significantly altered airway or systemic inflammation in asthmatic children. However, the higher prevalence of non-eosinophilic asthma in female obese asthmatics, compared to males, warrants further investigation.