RT Journal Article
SR Electronic
T1 The role of mannose-binding lectin on pneumococcal infection
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01741-2011
DO 10.1183/09031936.00174111
A1 M. Isabel García-Laorden
A1 Felipe Rodríguez de Castro
A1 Jordi Solé-Violán
A1 Antoni Payeras
A1 M. Luisa Briones
A1 Luis Borderías
A1 Javier Aspa
A1 José Blanquer
A1 Olga Rajas
A1 J. Alberto Marcos-Ramos
A1 Estefanía Herrera-Ramos
A1 Miguel A. García-Bello
A1 Judith Noda
A1 José M. Ferrer
A1 Jordi Rello
A1 Carlos Rodríguez-Gallego
YR 2012
UL http://erj.ersjournals.com/content/early/2012/04/19/09031936.00174111.abstract
AB The role of mannose-binding lectin (MBL) deficiency (MBL2 XA/O + O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, another collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of linkage disequilibrium (LD) of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed.MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We evidenced the existence of LD between MBL2 and SPs genes.The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases.