RT Journal Article
SR Electronic
T1 Prenatal exposure to DDE and infant's lower respiratory tract infections and wheeze
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00117-2011
DO 10.1183/09031936.00011711
A1 M. Gascon
A1 M. Vrijheid
A1 D. Martínez
A1 F. Ballester
A1 M. Basterrechea
A1 E. Blarduni
A1 A. Esplugues
A1 E. Vizcaino
A1 J.O. Grimalt
A1 E. Morales
A1 J. Sunyer
A1 on behalf of the INMA project
YR 2012
UL http://erj.ersjournals.com/content/early/2011/11/09/09031936.00011711.abstract
AB to examine whether prenatal exposure to dichlorodiphenyldichloroethylene (DDE) increases the risk of lower respiratory tract infections (LRTI) and wheeze in infants.the study is based on a birth cohort of 1455 mother-child pairs. Maternal serum concentrations of DDE, polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) were measured during pregnancy. Parental reports on LRTI and wheeze were obtained when children were 12–14 months old.35.4% of children developed at least one LRTI episode and 33.6% at least one wheezing episode during their first 12–14 months of life. Median DDE, PCBs, and HCB concentrations were 116.3, 113.7 and 46.4 ng·g−1 lipid, respectively. DDE concentrations were associated with LRTI risk (relative risk (RR) per 10% increase (95%CI) 1.11 (1.00, 1.22)), also after adjustment for PCBs and HCB. In all quartiles of DDE exposure the risk of LRTI was increased compared to the lowest quartile, but the increase was statistically significant only in the 3rd quartile (RR (95%CI) 1.33 (1.08, 1.62)). No association was observed for PCBs and HCB. Results were similar for wheeze.This study suggests that prenatal DDE exposure is associated with a higher risk of LRTI and wheeze in infants independently from exposure to other organochlorine compounds.