@article {Bartziokaserj02092-2012, author = {Konstantinos Bartziokas and Andriana I. Papaioannou and Stelios Loukides and Alexandros Papadopoulos and Aikaterini Haniotou and Spyridon Papiris and Konstantinos Kostikas}, title = {Serum uric acid on COPD exacerbation as predictor of mortality and future exacerbations}, elocation-id = {erj02092-2012}, year = {2013}, doi = {10.1183/09031936.00209212}, publisher = {European Respiratory Society}, abstract = {Serum uric acid (UA) is increased in respiratory disease, especially in the presence of hypoxia and systemic inflammation. We evaluated serum UA as a biomarker for prediction of mortality and future AECOPD.Serum UA was measured in 314 eligible consecutive patients on admission for acute exacerbation of COPD (AECOPD). Patients were evaluated monthly for 1 year.UA levels were higher in patients with more severe airflow limitation and in frequent exacerbators. High UA levels (>=6.9 mg{\textperiodcentered}dL-1, median value) were an independent predictor of 30-day mortality in multivariate Cox regression analysis [hazard ratio (HR) 1.327, 95\%CI 1.021{\textendash}1.726; p=0.034], but not of 1-year mortality. Patients with high serum UA required more prolonged hospitalisation, and needed more often non-invasive ventilation and ICU admission in 30 days. High UA was additionally associated with increased risk for AECOPD and hospitalisations for AECOPD in 1-year in multivariate Poisson regression analysis [incidence rate ratios (IRR) 1.184 (95\%CI 1.125{\textendash}1.246), p\<0.001 and 1.190 (95\%CI 1.105{\textendash}1.282), respectively; both p\<0.001].Serum UA is associated with increased 30-day mortality and risk for AECOPD and hospitalisations in 1-year follow-up. This low-cost biomarker may be useful in the identification of high-risk COPD patients that could benefit from intensive management.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/early/2013/05/03/09031936.00209212}, eprint = {https://erj.ersjournals.com/content/early/2013/05/03/09031936.00209212.full.pdf}, journal = {European Respiratory Journal} }