TY - JOUR T1 - Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00033011 SP - erj00330-2011 AU - J. Hetzel AU - R. Eberhardt AU - F.J. Herth AU - C. Petermann AU - G. Reichle AU - L. Freitag AU - I. Dobbertin AU - K.J. Franke AU - F. Stanzel AU - T. Beyer AU - P. Möller AU - P. Fritz AU - G. Ott AU - P.A.Schnabel AU - H. Kastendieck AU - W. Lang AU - A.T. Morresi-Hauf AU - M.N. Szyrach AU - R. Muche AU - P.L. Shah AU - A. Babiak AU - M. Hetzel Y1 - 2011/01/01 UR - http://erj.ersjournals.com/content/early/2011/08/05/09031936.00033011.abstract N2 - Currently the use of forceps, brushes or needles during flexible bronchoscopy are the standard tools when diagnosing endobronchial malignancies. The new biopsy technique of cryobiopsy appears to provide better diagnostic samples. The aim of this study was to evaluate cryobiopsy over conventional endobronchial sampling. A total of 600 patients in 8 centres with suspected endobronchial tumours were included in a prospective, randomized, single blinded multi-centre study. Patients were randomized either to sampling using forceps or the cryoprobe. After obtaining biopsy samples a blinded histological evaluation was performed. According to the definitive clinical diagnosis the diagnostic yield for malignancy was evaluated by a chi-square test. A total of 593 patients were randomised, of which 563 had a final diagnosis of cancer. 281 patients were randomized to endobronchial biopsies using forceps and 282 had biopsies performed using a flexible cryoprobe. A definitive diagnosis was achieved in 85.1% of patients randomized to conventional forceps biopsy and 95.0% of patients who underwent cryobiopsy (p<0.001). Importantly, there was no difference in the incidence of significant bleeding. Endobronchial cryobiopsy is a safe technique with superior diagnostic yield in comparison to conventional forceps biopsy. ER -