RT Journal Article
SR Electronic
T1 Development of a decision tree to assess the severity and prognosis of stable COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01890-2010
DO 10.1183/09031936.00189010
A1 Esteban, C.
A1 Arostegui, I.
A1 Moraza, J.
A1 Aburto, M.
A1 Quintana, J.M.
A1 Pérez-Izquierdo, J.
A1 Aizpiri, S.
A1 Capelastegui, A.
YR 2011
UL http://erj.ersjournals.com/content/early/2011/05/12/09031936.00189010.abstract
AB The aim of this study was to develop and validate a new method: a classification and regression tree (CART) based on easily accessible measures to predict mortality in patients with stable COPD.Prospective study of two independent prospective cohorts: a derivation cohort with 611 recruited patients and a validation cohort with 348 patients, all followed for 5 years. CART analysis was used to predict 5-year mortality risk using the following covariates from the derivation cohort: age, forced expiratory volume in the first second as a percentage of predicted (FEV1%), dyspnoea, physical activity, general health, and number of hospital admissions for COPD exacerbations in the prior 2 years.Age (≥75 years or <75) provided the first branch of the COPD-CART. The highest mortality risk (0.74) was seen in patients older than 75 with higher levels of dyspnoea and with FEV1% <50%. Patients with the lowest risk of 5-year mortality (0.04) were those under age 55 years with FEV1% >35% and with 1 or no recent hospitalizations for COPD exacerbations.A simple decision tree that uses variables generally gathered by physicians can provide a quick assessment of the severity of the disease, as measured by the risk of 5-year mortality.