RT Journal Article
SR Electronic
T1 Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00598-2010
DO 10.1183/09031936.00059810
A1 M. Okamoto
A1 T. Hoshino
A1 Y. Kitasato
A1 Y. Sakazaki
A1 T. Kawayama
A1 K. Fujimoto
A1 K. Ohshima
A1 H. Shiraishi
A1 M. Uchida
A1 J. Ono
A1 S. Ohta
A1 S. Kato
A1 K. Izuhara
A1 H. Aizawa
YR 2011
UL http://erj.ersjournals.com/content/early/2010/12/22/09031936.00059810.abstract
AB Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP). In this study, we addressed whether periostin, a matrix protein, could be a biomarker to assess histopathological types of IIPs. To accomplish this objective, we performed immunohistochemical analyses in each histopathological type of IIP, we examined serum levels of periostin in IIPs patients and we analysed the relationship between serum levels of periostin and the pulmonary functions in patients with idiopathic pulmonary fibrosis (IPF). Periostin was strongly expressed in lungs of UIP and fibrotic NSIP patients, whereas expression of periostin was weak in lungs of cellular NSIP and COP patients as well as in normal lungs. Serum levels of periostin in IPF were significantly higher than those of healthy subjects and COP patients. Furthermore, periostin levels in IPF patients were inversely correlated with their pulmonary functions. Thus, we have found that periostin is a novel component of fibrosis in IIPs. Periostin may be a potential biomarker to distinguish IIPs with fibrosis that may have progressive disease.