RT Journal Article
SR Electronic
T1 The effect of spontaneous breathing on systemic interleukin-6 during ventilator weaning
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00375-2011
DO 10.1183/09031936.00037511
A1 J. Sellares
A1 H. Loureiro
A1 M. Ferrer
A1 R. Amaro
A1 R. Farré
A1 A. Torres
YR 2011
UL http://erj.ersjournals.com/content/early/2011/07/12/09031936.00037511.abstract
AB During the weaning process, spontaneous breathing trial (SBT) involves cardiopulmonary stress for ventilated patients. As interleukin [IL]-6 is a major modulator of the stress response, we hypothesized that systemic IL-6 increases during the SBT and that this increase is more evident in SBT failure.Forty-nine SBTs of 30-minute duration were performed on different mechanically-ventilated patients, classified as SBT failure or success. Blood samples were drawn before and at the end of the SBT. An additional sample was drawn 24 hours later in a subset of patients (n=39). Serum IL-6 levels and other inflammatory mediators commonly associated with stress were determined.IL-6 levels increased from mechanical ventilation to spontaneous breathing in all patients (p=0.02) and in COPD population (p=0.05) with SBT failure compared to success, but not in non-COPD patients (p=0.12). After 24 hours of SBT stress, IL-6 levels decreased in patients with SBT failure (under MV at that point) (p=0.02) and those with weaning success (p=0.04). No changes were observed in the remaining inflammatory mediators.Systemic IL-6 increases during a 30-minute failed SBT, especially in COPD patients. Future studies may corroborate the different IL-6 responses among different populations who initiate weaning, together with the potential clinical implications.