RT Journal Article
SR Electronic
T1 HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00250-2011
DO 10.1183/09031936.00025011
A1 P. Darlington
A1 L. Tallstedt
A1 L. Padyukov
A1 I. Kockum
A1 K. Cederlund
A1 A. Eklund
A1 J. Grunewald
YR 2011
UL http://erj.ersjournals.com/content/early/2011/06/09/09031936.00025011.abstract
AB Heerfordt's syndrome (HS), consists in its complete form of uveitis, parotid or salivary gland enlargement and cranial nerve palsy. The objective of the present study was to analyse if there are links also between HLA-DRB1* alleles and HS, since it is a specific phenotype of sarcoidosis.1000 patients with sarcoidosis, out of which 83 had symptoms associated with HS, were included in the study together with a group of 2000 healthy individuals from the same population, matched for gender and age. HLA-DRB1* allelic groups were determined for all individuals, and comparisons were made between different disease subgroups and between patients and healthy controls.We found that the HLA-DRB1*04 allele was overrepresented in patients with symptoms associated with HS. Eighty-three (8.3%) of all patients had one or more of the symptoms and forty-six (55%) of them were HLA-DRB1*04 positive. Forty-four (55%) of the patients with ocular sarcoidosis, i.e. the most common symptom associated with HS, were HLA-DRB1*04 positive, compared to 35.9% of healthy controls (p=0.0008), and only 26.6% of the whole group of sarcoidosis patients (p<0.0001).HLA-DRB1*04 seems to protect against overall sarcoidosis, but to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS.