Supplementary material
Supplementary material
Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.
- Online supplementary table S1
- Online supplementary table S2
- Online supplementary table S3
- Online supplementary table S4
- Online supplementary table S5
- Online supplementary figure S1 - Morphological characteristics of SQCC. Representative examples of keratinizing (A) non-keratinizing (B), and basaloid SQCC (C) as well as an overview (D) and details (E, F) of budding at the tumour invasion front. (G) exemplifies an overview of a case with extensive formation of tumour cell nests, details of tumour cell nests are depicted in (H, I). The last column shows SQCC cases with low (J), moderate (K), and high (L) stromal content.
- Online supplementary figure S2 - Association of histologic types with budding activity and nest size. (A) Association of budding activity (both per 1 HPF as well as per 10 HPF) with SQCC subtype. (B) Association of overall nest size as well as nest size at the margin with SQCC subtype.
- Online supplementary figure S3 - Association of histologic types with survival in SQCC. The impact of the specific histologic type on overall (A) as well as disease free survival (B) is depicted.
- Online supplementary figure S4 - Association of histologic types with survival in SQCC stratified for adjuvant chemotherapy. The impact of the specific histologic types on overall survival is depicted separately for patients who did not (A) and those patients who received adjuvant chemotherapy (B).
- Online supplementary figure S5 - Association of budding activity with survival in SQCC. The impact of tumor cell budding on overall (A) as well as disease free (B/C) survival is depicted for budding foci per one HPF (A/B) as well as 10 HPF (C).
- Online supplementary figure S6 - Association of nest size with survival in SQCC. The impact of tumour nest size on overall (B) as well as disease free (A/C) survival is depicted for overall tumour nest size (A) as well as for tumour nest size at the invasive margin (B/C).
- Online supplementary figure S7 - Association of nuclear size and stromal component with survival in SQCC. The impact on overall (A/C) as well as disease free (B/D) survival is depicted for nuclear size (A/B) as well as for the stromal content (C/D).
- Online supplementary figure S8 - Association of additive grading scores with survival in SQCC. The impact on overall (A) as well as disease free (B) survival is depicted for the "raw" non-grouped additive grading scores (for details see text).
- Online supplementary figure S9 - Association of the proposed grading scheme with disease free survival.