Supplementary methods, figures and tables

Supplementary methods, figures and tables

Methods: ensemble average; repeatability test; reproducibility test; expiratory flow limitation. Fig. E1-a. Whisker plots of ∆θ during exercise in the control group (n=10). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E1-b. Whisker plots of ∆IP during exercise in the control group (n=10). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise Fig. E2-a. Whisker plots of ∆θ during exercise in the COPD group (n=14). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E2-b. Whisker plots of ∆IP during exercise in the COPD group (n=14). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E3-a. Phase shift (θ) during QB in the 3 tests. Black circles: Subject #3, white circles: Subject #5, black triangles: Subject #12, dashed straight line: threshold. Fig. E3-b.Inspiratory Paradox time (IP) during QB in the 3 tests. Black circles: Subject #3, white circles: Subject #5, black triangles: Subject #12, dashed straight line: threshold. Fig. E4. Left panels: dynamic flow-volume loops during quiet breathing, maximal exercise and forced expiratory maneuver. Right panels: dynamic loop of volume changes of pulmonary rib cage vs abdominal rib cage during quiet breathing (thin lines) and maximal exercise (thick line). Closed circles: end-expiration; closed triangles: end-inspiration; arrows: direction of the loops. Volumes of each compartment is referred to mean end-expiratory volume of that compartment at rest. In figures E4-a and E4-b are reported data of P+ patients, while in figures E4-c, E4-d and E4-e data of P- patients. Fig. E5. Volume variations of upper (solid lines) and lower (dashed lines) rib cage during quiet breathing (black lines) and maximal exercise (blue lines). As in fig. E4, volumes of each compartment is referred to mean end-expiratory volume of that compartment at rest. In figures E5-a are reported data of P+ patients, while in figures E5-b and E5-c data of P- patients.

Files in this Data Supplement:

  • Supplementary methods, figures and tables - Methods: ensemble average; repeatability test; reproducibility test; expiratory flow limitation. Fig. E1-a. Whisker plots of ∆θ during exercise in the control group (n=10). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E1-b. Whisker plots of ∆IP during exercise in the control group (n=10). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise Fig. E2-a. Whisker plots of ∆θ during exercise in the COPD group (n=14). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E2-b. Whisker plots of ∆IP during exercise in the COPD group (n=14). Grey boxes: lower limit: 25th percentile, upper limit 75th percentile, continuous line: median, dashed line: mean. Error bars: 10th and 90th percentile. Black dots: 5th and 95th percentile. QB: quiet breathing, UL: unloaded exercise. Fig. E3-a. Phase shift (θ) during QB in the 3 tests. Black circles: Subject #3, white circles: Subject #5, black triangles: Subject #12, dashed straight line: threshold. Fig. E3-b.Inspiratory Paradox time (IP) during QB in the 3 tests. Black circles: Subject #3, white circles: Subject #5, black triangles: Subject #12, dashed straight line: threshold. Fig. E4. Left panels: dynamic flow-volume loops during quiet breathing, maximal exercise and forced expiratory maneuver. Right panels: dynamic loop of volume changes of pulmonary rib cage vs abdominal rib cage during quiet breathing (thin lines) and maximal exercise (thick line). Closed circles: end-expiration; closed triangles: end-inspiration; arrows: direction of the loops. Volumes of each compartment is referred to mean end-expiratory volume of that compartment at rest. In figures E4-a and E4-b are reported data of P+ patients, while in figures E4-c, E4-d and E4-e data of P- patients. Fig. E5. Volume variations of upper (solid lines) and lower (dashed lines) rib cage during quiet breathing (black lines) and maximal exercise (blue lines). As in fig. E4, volumes of each compartment is referred to mean end-expiratory volume of that compartment at rest. In figures E5-a are reported data of P+ patients, while in figures E5-b and E5-c data of P- patients.