ERJ Early View

ERJ Early View manuscripts have recently been accepted for publication in the European Respiratory Journal. They are published here in their accepted form, prior to copyediting and typesetting. After these production processes are complete and the authors have approved the resulting proofs, articles move to the latest issue of the ERJ online.

February 03, 2022

Review
The discovAIR project: a roadmap towards the Human Lung Cell Atlas
Malte D. Luecken, Laure-Emmanuelle Zaragosi, Elo Madissoon, Lisa Sikkema, Alexandra B. Firsova, Elena De Domenico, Louis Kümmerle, Adem Saglam, Marijn Berg, Aurore C.A. Gay, Janine Schniering, Christoph H. Mayr, Xesús M. Abalo, Ludvig Larsson, Alexandros Sountoulidis, Sarah Teichmann, Karen van Eunen, Gerard H. Koppelman, Kourosh Saeb-Parsy, Sylvie Leroy, Pippa Powell, Ugis Sarkans, Wim Timens, Joakim Lundeberg, Maarten van den Berge, Mats Nilsson, Peter Horváth, Jessica Denning, Irene Papatheodorou, Joachim Schultze, Herbert B. Schiller, Pascal Barbry, Ilya Petoukhov, Alexander V. Misharin, Ian Adcock, Michael von Papen, Fabian J. Theis, Christos Samakovlis, Kerstin B. Meyer, Martijn C. Nawijn

European Respiratory Journal; DOI: 10.1183/13993003.02057-2021
Original research article
A Polygenic Risk Score and Age of Diagnosis of Chronic Obstructive Pulmonary Disease
Jingzhou Zhang, Hanfei Xu, Dandi Qiao, Dawn L. DeMeo, Edwin K. Silverman, George T. O'Connor, Brian D. Hobbs, Josée Dupuis, Michael H. Cho, Matthew Moll

European Respiratory Journal; DOI: 10.1183/13993003.01954-2021
Original research article
Interstitial lung abnormalities are associated with decreased mean telomere length
Rachel K. Putman, Gisli Thor Axelsson, Samuel Y. Ash, Jason L. Sanders, Aravind A. Menon, Tetsuro Araki, Mizuki Nishino, Masahiro Yanagawa, Elías F. Gudmundsson, Dandi Qiao, Raúl San José Estépar, Josée Dupuis, George T. O'Connor, Ivan O. Rosas, George R. Washko, Souheil El-Chemaly, Benjamin A. Raby, Vilmundur Gudnason, Dawn L. DeMeo, Edwin K. Silverman, Hiroto Hatabu, Immaculata DeVivo, Michael H. Cho, Gunnar Gudmundsson, Gary M. Hunninghake

European Respiratory Journal; DOI: 10.1183/13993003.01814-2021
Perspective
The role of precision medicine in interstitial lung disease
Toby M. Maher, Anoop M. Nambiar, Athol U. Wells

European Respiratory Journal; DOI: 10.1183/13993003.02146-2021
Original research article
Effect of Interleukin-6 Receptor Antagonists in Critically Ill Adult Patients with COVID-19 Pneumonia: two Randomised Controlled Trials of the CORIMUNO-19 Collaborative Group
Olivier Hermine, Xavier Mariette, Raphael Porcher, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Philippe Ravaud on the behalf of the CORIMUNO-19 collaborative group

European Respiratory Journal; DOI: 10.1183/13993003.02523-2021
Original research article
Static mucus impairs bacterial clearance and allows chronic infection with Pseudomonas aeruginosa in the cystic fibrosis rat
Alexander G. Henderson, Joy M. Davis, Johnathan D. Keith, Morgan E. Green, Ashley M. Oden, Steven M. Rowe, Susan E Birket

European Respiratory Journal; DOI: 10.1183/13993003.01032-2021

January 27, 2022

Original research article
Forskolin-induced Organoid Swelling is Associated with Long-term CF Disease Progression
Danya Muilwijk, Eyleen de Poel, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Evelien Kruisselbrink, Hugo Oppelaar, Marne C. Hagemeijer, Gitte Berkers, Karin M. de Winter-de Groot, Sabine Heida-Michel, Stephan R. Jans, Hannah van Panhuis, Menno M. van der Eerden, Renske van der Meer, Jolt Roukema, Edward Dompeling, Els. J.M. Weersink, Gerard H. Koppelman, Robert Vries, Domenique D. Zomer-van Ommen, Marinus .J.C. Eijkemans, Cornelis K. van der Ent, Jeffrey M. Beekman

European Respiratory Journal; DOI: 10.1183/13993003.00508-2021
Original research article
The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
Yi Wang, Lei Zhang, Teng Huang, Guo-Rao Wu, Qing Zhou, Fa-Xi Wang, Long-Min Chen, Fei Sun, Yongman Lv, Fei Xiong, Shu Zhang, Qilin Yu, Ping Yang, Weikuan Gu, Yongjian Xu, Jianping Zhao, Huilan Zhang, Weining Xiong, Cong-Yi Wang

European Respiratory Journal; DOI: 10.1183/13993003.03697-2020
Original research article
Improved prediction of asthma exacerbations by measuring distal airway inflammation
Emmanouil Paraskakis, Evangelia Sarikloglou, Sotirios Fouzas, Paschalis Steiropoulos, Aggelos Tsalkidis, Andrew Bush

European Respiratory Journal; DOI: 10.1183/13993003.01684-2021
Correspondence
Diversity of approaches in artificial intelligence: an opportunity for discoveries in thoracic imaging
Guillaume Chassagnon, Alienor Campredon, Maria Vakalopoulou, Pierre-Régis Burgel

European Respiratory Journal; DOI: 10.1183/13993003.00022-2022
Review
Allergen Provocation Tests in Respiratory Research: Building on 50 Years of Experience
Gail M. Gauvreau, Beth E. Davis, Guy Scadding, Louis-Philippe Boulet, Leif Bjermer, Adam Chaker, Donald W. Cockcroft, Barbro Dahlén, Wyste Fokkens, Peter Hellings, Nikolaos Lazarinis, Paul M. O'Byrne, Ellen Tufvesson, Santiago Quirce, Maurits Van Maaren, Frans H. de Jongh, Zuzana Diamant

European Respiratory Journal; DOI: 10.1183/13993003.02782-2021
Correspondence
Radiomics derived morphological features predict pulmonary function response under lumacaftor-ivacaftor in patients with cystic fibrosis
Bin Zhang, Shuixing Zhang

European Respiratory Journal; DOI: 10.1183/13993003.03077-2021

January 20, 2022

Original research article
Flavonoid intakes inversely associate with chronic obstructive pulmonary disease in smokers
Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyrø, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson

European Respiratory Journal; DOI: 10.1183/13993003.02604-2021
Original research article
Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection
Joshua J.C. McGrath, Gilles Vanderstocken, Anna Dvorkin-Gheva, Steven P. Cass, Sam Afkhami, Matthew F. Fantauzzi, Danya Thayaparan, Amir Reihani, Peiyao Wang, Ashley Beaulieu, Pamela Shen, Mathieu Morissette, Rodrigo Jiménez-Saiz, Spencer D. Revill, Arata Tabuchi, Diana Zabini, Warren L. Lee, Carl D. Richards, Matthew S. Miller, Kjetil Ask, Wolfgang M. Kuebler, Jeremy A. Simpson, Martin R. Stämpfli

European Respiratory Journal; DOI: 10.1183/13993003.02049-2021
Original research article
Biomarkers to identify Mycobacterium tuberculosis-infection among borderline QuantiFERON results
Jonathan W. Uzorka, Jaap A. Bakker, Krista E. van Meijgaarden, Eliane M.S. Leyten, Nathalie M. Delfos, David J. Hetem, Jos Kerremans, Mieke Zwarts, Sandra Cozijn, Tom H.M. Ottenhoff, Simone A. Joosten, Sandra M. Arend

European Respiratory Journal; DOI: 10.1183/13993003.02665-2021
Original research article
Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension
Nabham Rai, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Grégoire Manaud, Swathi Veeroju, Clemens Ruppert, Frédéric Perros, Hossein Ardeschir Ghofrani, Norbert Weissmann, Werner Seeger, Ralph T. Schermuly, Tatyana Novoyatleva

European Respiratory Journal; DOI: 10.1183/13993003.01698-2021
Series
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Daniela Riccardi, Jeremy PT Ward, Polina L Yarova, Luke J Janssen, Tak Hong Lee, Sun Ying, Chris J Corrigan

European Respiratory Journal; DOI: 10.1183/13993003.02103-2021

January 13, 2022

Original research article
Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma
Taha Al-Shaikhly, Ryan C. Murphy, Andrew Parker, Ying Lai, Matthew C. Altman, Megan Larmore, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Michael C. Peters, Teal S. Hallstrand

European Respiratory Journal; DOI: 10.1183/13993003.01865-2021

January 07, 2022

Original research article
The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community
Jenna McNeill, Ariel Chernofsky, Matthew Nayor, Farbod N. Rahaghi, Raul San Jose Estepar, George Washko, Andrew Synn, Ramachandran S. Vasan, George O'Connor, Martin G. Larson, Jennifer E. Ho, Gregory D. Lewis

European Respiratory Journal; DOI: 10.1183/13993003.01821-2021
Original research article
Echocardiographic probability of pulmonary hypertension: a validation study
Michele D'Alto, Marco Di Maio, Emanuele Romeo, Paola Argiento, Ettore Blasi, Alessandro Di Vilio, Gaetano Rea, Antonello D'Andrea, Paolo Golino, Robert Naeije

European Respiratory Journal; DOI: 10.1183/13993003.02548-2021
Original research article
Vulnerability to acid reflux of the airway epithelium in severe asthma
Jeanne-Marie Perotin, Gabrielle Wheway, Kamran Tariq, Adnan Azim, Robert A Ridley, Jonathan A Ward, James PR Schofield, Clair Barber, Peter Howarth, Donna E. Davies, Ratko Djukanovic

European Respiratory Journal; DOI: 10.1183/13993003.01634-2021
Original research article
CFTR variants are associated with chronic bronchitis in smokers
Aabida Saferali, Dandi Qiao, Wonji Kim, Karen Raraigh, Hara Levy, Alejandro A. Diaz, Garry R. Cutting, Michael H. Cho, Craig P. Hersh NHLBI TransOmics in Precision Medicine (TOPMed)

European Respiratory Journal; DOI: 10.1183/13993003.01994-2021
Original research article
Lysyl oxidase-like 2 is increased in asthma and contributes to asthmatic airway remodelling
Jopeth Ramis, Robert Middlewick, Francesco Pappalardo, Jennifer T. Cairns, Iain D. Stewart, Alison E. John, Shams-Un-Nisa Naveed, Ramaswamy Krishnan, Suzanne Miller, Dominick E. Shaw, Christopher E. Brightling, Lee Buttery, Felicity Rose, Gisli Jenkins, Simon R. Johnson, Amanda L Tatler

European Respiratory Journal; DOI: 10.1183/13993003.04361-2020

December 23, 2021

Original research article
Impact of Hepatopulmonary Syndrome in Liver Transplantation Candidates and the Role of Angiogenesis
Steven M. Kawut, Michael J. Krowka, Kimberly A. Forde, Nadine Al-Naamani, Karen L. Krok, Mamta Patel, Carlo R. Bartoli, Margaret Doyle, Jude Moutchia, Grace Lin, Jae K. Oh, Carl D. Mottram, Paul D. Scanlon, Michael B. Fallon, for the Pulmonary Vascular Complications of Liver Disease Study Group

European Respiratory Journal; DOI: 10.1183/13993003.02304-2021
Original research article
A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement
Rachel M Mercer, Eleanor Mishra, Radhika Banka, John P Corcoran, Cyrus Daneshvar, Rakesh K Panchal, Tarek Saba, Melanie Caswell, Sarah Johnstone, Daniel Menzies, Sana Ahmer, Mitra Shahidi, Amelia O Clive, Manish Gautam, Giles Cox, Chris Orton, Judith Lyons, Nadeem Maddekar, Duneesha De Fonseka, Kathryn Prior, Simon Barnes, Grace Robinson, Louise Brown, Mohammed Munavvar, Palav L Shah, Robert J Hallifax, Kevin G Blyth, Emma Hedley, Nick A Maskell, Stephen Gerry, Robert F Miller, Najib M Rahman, Samuel V Kemp

European Respiratory Journal; DOI: 10.1183/13993003.01753-2021
Task force report
ERS/ATS technical standard on interpretive strategies for routine lung function tests
Sanja Stanojevic, David A. Kaminsky, Martin Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G. Cooper, Bruce Culver, Eric Derom, Graham L. Hall, Teal S. Hallstrand, Joerg D. Leuppi, Neil MacIntyre, Meredith McCormack, Margaret Rosenfeld, Erik R. Swenson

European Respiratory Journal; DOI: 10.1183/13993003.01499-2021
Original research article
Chronic lung allograft dysfunction phenotype and prognosis by machine learning CT analysis
Micheal C. McInnis, Jin Ma, Gauri Rani Karur, Christian Houbois, Liran Levy, Jan Havlin, Eyal Fuchs, Jussi Tikkanen, Chung-Wai Chow, Ella Huszti, Tereza Martinu

European Respiratory Journal; DOI: 10.1183/13993003.01652-2021
Original research article
Fine particles matter components and interstitial lung disease in rheumatoid arthritis
Naizhuo Zhao, Ziyad Al-Aly, Boyang Zheng, Aaron van Donkelaar, Randall V. Martin, Christian A. Pineau, Sasha Bernatsky

European Respiratory Journal; DOI: 10.1183/13993003.02149-2021

December 16, 2021

Original research article
Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 Pneumonia: an open-label, randomised clinical trial
Manuel Taboada, Nuria Rodríguez, Pablo Manuel Varela, María Teresa Rodríguez, Romina Abelleira, Amara González, Ana Casal, José Antonio Díaz Peromingo, Adriana Lama, María Jesús Domínguez, Carlos Rábade, Emilio Manuel Páez, Vanessa Riveiro, Hadrián Pernas, María del Carmen Beceiro, Valentín Caruezo, Alberto Naveira, Agustín Cariñena, Teresa Cabaleiro, Ana Estany-Gestal, Irene Zarra, Antonio Pose, Luis Valdés, Julián Álvarez-Escudero

European Respiratory Journal; DOI: 10.1183/13993003.02518-2021
Original research article
Nasopharyngeal metatranscriptome profiles of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study
Yoshihiko Raita, Marcos Pérez-Losada, Robert J. Freishtat, Andrea Hahn, Eduardo Castro-Nallar, Ignacio Ramos-Tapia, Nathaniel Stearrett, Yury A. Bochkov, James E. Gern, Jonathan M. Mansbach, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa

European Respiratory Journal; DOI: 10.1183/13993003.02293-2021
Original research article
Evaluation of a novel CFTR potentiator in copd ferrets with acquired cftr dysfunction
Niroop Kaza, Vivian Y. Lin, Denise Stanford, Shah S. Hussain, Emily Falk Libby, Harrison Kim, Monica Borgonovi, Katja Conrath, Venkateshwar Mutyam, Stephen A. Byzek, Li Ping Tang, John E. Trombley, Lawrence Rasmussen, Trenton Schoeb, Hui Min Leung, Guillermo J. Tearney, S. Vamsee Raju, Steven M. Rowe

European Respiratory Journal; DOI: 10.1183/13993003.01581-2021
State of the art
The environmental impact of inhaled therapy: making informed treatment choices
Ashley Woodcock, Kai M. Beeh, Hironori Sagara, Simon Aumônier, Emmanuel Addo-Yobo, Javaid Khan, Jørgen Vestbo, Helen Tope

European Respiratory Journal; DOI: 10.1183/13993003.02106-2021
Original research article
Phenotype and severity of asthma determines bronchial epithelial immune responses to a viral mimic
Celeste Porsbjerg, Juan Jose Nieto-Fontarigo, Samuel Cerps, Sangheeta Ramu, Mandy Menzel, Morten Hvidtfeldt, Alexander Silberbrandt, Laurits Froessing, Ditte Klein, Asger Sverrild, Lena Uller

European Respiratory Journal; DOI: 10.1183/13993003.02333-2021

December 09, 2021

Original research article
Mechanical ventilation promotes lung tumor spread by modulation of cholesterol cell content
Inés López-Alonso, Cecilia López-Martínez, Paula Martín-Vicente, Laura Amado-Rodríguez, Adrián González-López, Juan Mayordomo-Colunga, Cecilia del Busto, Marina Bernal, Irene Crespo, Aurora Astudillo, Miguel Arias-Guillén, Antonio Fueyo, Isaac Almendros, Jorge Otero, Héctor Sanz-Fraile, Ramón Farré, Guillermo M Albaiceta

European Respiratory Journal; DOI: 10.1183/13993003.01470-2021
Original research article
Prognostic phenotypes of early-stage lung adenocarcinoma
Anne-Sophie Lamort, Jan Christian Kaiser, Mario A.A. Pepe, Ioannis Lilis, Giannoula Ntaliarda, Kalman Somogyi, Magda Spella, Sabine J. Behrend, Georgia A. Giotopoulou, Willem Kujawa, Michael Lindner, Ina Koch, Rudolf A. Hatz, Juergen Behr, Rocio Sotillo, Andrea C. Schamberger, Georgios T. Stathopoulos

European Respiratory Journal; DOI: 10.1183/13993003.01674-2021

December 02, 2021

Original research article
Co-morbid insomnia and obstructive sleep apnoea is associated with all-cause mortality
Bastien Lechat, Sarah Appleton, Yohannes Adama Melaku, Kristy Hansen, R. Doug McEvoy, Robert Adams, Peter Catcheside, Leon Lack, Danny J Eckert, Alexander Sweetman

European Respiratory Journal; DOI: 10.1183/13993003.01958-2021
Original research article
Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes
Mingxia Du, Haibin Jiang, Hongxian Liu, Xin Zhao, Yu Zhou, Fang Zhou, Chunmei Piao, Guoqiang Xu, Feng Ma, Jianan Wang, Frederic Perros, Nicholas W Morrell, Hong Gu, Jun Yang

European Respiratory Journal; DOI: 10.1183/13993003.00327-2021

November 25, 2021

Original research article
Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Kristina Crothers, Rian DeFaccio, Janet Tate, Patrick R. Alba, Matthew Bidwell Goetz, Barbara Jones, Joseph T. King, Vincent Marconi, Michael E. Ohl, Christopher T. Rentsch, Maria C. Rodriguez-Barradas, Shahida Shahrir, Amy C. Justice, Kathleen M. Akgün, Veterans Aging Cohort Study Clinical COVID-19 Working Group

European Respiratory Journal; DOI: 10.1183/13993003.02532-2021
Original research article
Broadening symptom criteria improves early case identification in SARS-CoV-2 contacts
Hamish Houston, Seran Hakki, Timesh D Pillay, Kieran Madon, Nieves Derqui-Fernandez, Aleksandra Koycheva, Anika Singanayagam, Joe Fenn, Rhia Kundu, Emily Conibear, Robert Varro, Jessica Cutajar, Valerie Quinn, Lulu Wang, Janakan S Narean, Mica R Tolosa-Wright, Jack Barnett, Onn Min Kon, Richard Tedder, Graham Taylor, Maria Zambon, Neil Ferguson, Jake Dunning, Jonathan J Deeks, Ajit Lalvani

European Respiratory Journal; DOI: 10.1183/13993003.02308-2021
Original research article
Selexipag for the treatment of chronic thromboembolic pulmonary hypertension
Takeshi Ogo, Hiroto Shimokawahara, Hideyuki Kinoshita, Seiichiro Sakao, Kohtaro Abe, Satoaki Matoba, Hirohiko Motoki, Noriaki Takama, Junya Ako, Yasuhiro Ikeda, Shuji Joho, Hisataka Maki, Takahiro Saeki, Teruyasu Sugano, Ichizo Tsujino, Koichiro Yoshioka, Naoki Shiota, Shinichi Tanaka, Chieko Yamamoto, Nobuhiro Tanabe, Koichiro Tatsumi, for the Study Group

European Respiratory Journal; DOI: 10.1183/13993003.01694-2021

November 11, 2021

Original research article
Protective efficacy of 6-week regimen for latent tuberculosis infection treatment in rural China: 5-year follow-up of a randomised controlled trial
Henan Xin, Xuefang Cao, Haoran Zhang, Boxuan Feng, Ying Du, Bin Zhang, Dakuan Wang, Zisen Liu, Ling Guan, Fei Shen, Xueling Guan, Jiaoxia Yan, Yijun He, Yongpeng He, Zhusheng Quan, Shouguo Pan, Jianmin Liu, Qi Jin, Lei Gao

European Respiratory Journal; DOI: 10.1183/13993003.02359-2021

November 04, 2021

Original research article
COMPERA 2.0: A refined 4-strata risk assessment model for pulmonary arterial hypertension
Marius M. Hoeper, Christine Pausch, Karen M. Olsson, Doerte Huscher, David Pittrow, Ekkehard Grünig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J. Simon R. Gibbs, Marion Delcroix, H. Ardeschir Ghofrani, Da-Hee Park, Ralf Ewert, Harald Kaemmerer, Hans-Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Jürgen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Tobias J. Lange, Stephan Rosenkranz

European Respiratory Journal; DOI: 10.1183/13993003.02311-2021

July 29, 2021

Research letter
Smoking quantitatively increases risk for COVID-19
Fuquan Zhang, Ancha Baranova

European Respiratory Journal; DOI: 10.1183/13993003.01273-2021

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ERJ Early View

February 03, 2022

Review

Original research article

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Perspective

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January 27, 2022

Original research article

Original research article

Original research article

Correspondence

Review

Correspondence

January 20, 2022

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Series

January 13, 2022

Original research article

January 07, 2022

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December 23, 2021

Original research article

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Task force report

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December 16, 2021

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State of the art

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December 09, 2021

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December 02, 2021

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November 25, 2021

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November 11, 2021

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November 04, 2021

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July 29, 2021

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