Extract
In their excellent review, Pijnenburg, Frey, De Jongste, and Saglani discuss multiple factors likely involved in inception and pathogeneses of childhood asthma including treatments. They note significant heterogeneity of the disease, highlight inconsistent observations, and suggest that with common modes of classification phenotype stability may be poor. With development of multidimensional and systems biology approaches they envisage that well-defined subgroups of childhood asthma will be possible [1]. My comment rather builds on often overlooked clinical observations of association between clusters of epithelial cells, Creola bodies (Cb), in sputum samples in infants and subsequent development of asthma [2, 3].
Footnotes
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Conflict of interest: No conflict of interest
- Received March 11, 2021.
- Accepted September 20, 2022.
- Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
