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Creola bodies and pathogenesis of childhood asthma

Carl Persson
European Respiratory Journal 2022; DOI: 10.1183/13993003.01204-2022
Carl Persson
Professor emeritus, Laboratory Medicine, University Hospital of Lund, Lund, Sweden
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In their excellent review, Pijnenburg, Frey, De Jongste, and Saglani discuss multiple factors likely involved in inception and pathogeneses of childhood asthma including treatments. They note significant heterogeneity of the disease, highlight inconsistent observations, and suggest that with common modes of classification phenotype stability may be poor. With development of multidimensional and systems biology approaches they envisage that well-defined subgroups of childhood asthma will be possible [1]. My comment rather builds on often overlooked clinical observations of association between clusters of epithelial cells, Creola bodies (Cb), in sputum samples in infants and subsequent development of asthma [2, 3].

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This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: No conflict of interest

  • Received March 11, 2021.
  • Accepted September 20, 2022.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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Vol 61 Issue 1 Table of Contents
European Respiratory Journal: 61 (1)
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Creola bodies and pathogenesis of childhood asthma
Carl Persson
European Respiratory Journal Jan 2022, 2201204; DOI: 10.1183/13993003.01204-2022

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Creola bodies and pathogenesis of childhood asthma
Carl Persson
European Respiratory Journal Jan 2022, 2201204; DOI: 10.1183/13993003.01204-2022
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