Extract
Congratulations to Van Hulst et al. for their article on the influence of interleukin (IL)-5 blockade on blood eosinophils in severe asthma [1]. In their discussion, the authors state that it is unclear if ‘increased stimulation-induced expression of Suppressor Of Cytokine Signaling-3 (SOCS3) in eosinophils in IL-5-depleted conditions has biological consequences’. However, their data can be linked to that of Seki et al. [2] and McDowell et al. [3] to speculate that the signal for stronger IL-33-mediated induction of SOCS3 becomes clinically relevant at the time of a mepolizumab-emergent asthma attack.
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
No Conflict of Interest
- Received March 21, 2022.
- Accepted May 4, 2022.
- Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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