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Epigenetic age acceleration in obstructive sleep apnea is reversible with adherent treatment

Rene Cortese, David Sanz-Rubio, Leila Kheirandish-Gozal, José Maria Marin, David Gozal
European Respiratory Journal 2022; DOI: 10.1183/13993003.03042-2021
Rene Cortese
1Department of Child Health – Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, United States
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David Sanz-Rubio
2Translational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, Zaragoza, Spain
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Leila Kheirandish-Gozal
1Department of Child Health – Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, United States
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José Maria Marin
3Hospital Universitario Miguel Servet, IISAragón, University of Zaragoza, Zaragoza, Spain
4CIBER Enfermedades Respiratorias, Madrid, Spain
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David Gozal
1Department of Child Health – Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, United States
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Obstructive Sleep Apnea (OSA) leads to activation and propagation of oxidative stress and systemic inflammatory pathways, essentially mimicking accelerated biological aging (senescence) [1–3]. Biological aging is a complex and time-dependent deterioration of physiological processes with attendant morbidity and mortality. During aging there is continuous and accelerated accumulation of epigenetic changes manifesting either systemically or restricted to a specific tissue/cell type. Epigenetic Clocks or DNA Methylation Clocks, have emerged as valuable biological age prediction tools [4]. By regressing DNA methylation age on chronological age, epigenetic clocks can determine whether biological age acceleration occurs in certain diseases or in response to environmental factors [4]. Using this approach, age acceleration measurements in blood were abnormally high in the context of common conditions such as obesity, neurological diseases, and cigarette smoking [5].

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflicts of interest: Rene Cortese has nothing to disclose.

Conflicts of interest: David Sanz-Rubio has nothing to disclose.

Conflicts of interest: Leila Kheirandish-Gozal has nothing to disclose.

Conflicts of interest: José Maria Marin has nothing to disclose.

  • Received September 9, 2021.
  • Accepted January 5, 2022.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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Epigenetic age acceleration in obstructive sleep apnea is reversible with adherent treatment
Rene Cortese, David Sanz-Rubio, Leila Kheirandish-Gozal, José Maria Marin, David Gozal
European Respiratory Journal Jan 2022, 2103042; DOI: 10.1183/13993003.03042-2021

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Epigenetic age acceleration in obstructive sleep apnea is reversible with adherent treatment
Rene Cortese, David Sanz-Rubio, Leila Kheirandish-Gozal, José Maria Marin, David Gozal
European Respiratory Journal Jan 2022, 2103042; DOI: 10.1183/13993003.03042-2021
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