Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Improved prediction of asthma exacerbations by measuring distal airway inflammation

Emmanouil Paraskakis, Evangelia Sarikloglou, Sotirios Fouzas, Paschalis Steiropoulos, Aggelos Tsalkidis, Andrew Bush
European Respiratory Journal 2022; DOI: 10.1183/13993003.01684-2021
Emmanouil Paraskakis
1Paediatric Respiratory Unit, Department of Paediatrics, Heraklion University Hospital, University of Crete Medical School, Heraklion, Crete, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Emmanouil Paraskakis
  • For correspondence: eparaska@uoc.gr
Evangelia Sarikloglou
2Medical School, Democritus University of Thrace, Alexandroupolis, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sotirios Fouzas
3Paediatric Respiratory Unit, University Hospital of Patras, Patras, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sotirios Fouzas
Paschalis Steiropoulos
2Medical School, Democritus University of Thrace, Alexandroupolis, Greece
4Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aggelos Tsalkidis
2Medical School, Democritus University of Thrace, Alexandroupolis, Greece
5Department of Paediatrics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Bush
6Department of Paediatrics, National Heart and Lung Institute, London, UK
7Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Extract

The function of the distal airway generations has in the past been difficult to assess, and in particular spirometry is insensitive to small airway disease. Novel physiological tools such as the Forced Oscillation Technique (FOT) and multiple breath washout (MBW) have demonstrated that distal disease makes an important contribution to asthma severity. Distal obstruction may result from many different factors, including remodelling, inflammation, airway instability due to loss of alveolar tethering attachments and mucus plugging. Distal airway disease is known to independently contribute to the severity of airway hyper-responsiveness in asthma [1] but unsurprisingly there is a poor correlation between distal inflammation measured directly and physiological parameters [2–4]. Distal inflammation can be studied directly using transbronchial biopsy and has been implicated in the severity of asthma [5], but this invasive technique is not suitable for routine monitoring and especially not in children.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Emmanouil Paraskakis

Conflict of interest: Evangelia Sarikloglou

Conflict of interest: Sotirios Fouzas

Conflict of interest: Paschalis Steiropoulos

Conflict of interest: Aggelos Tsalkidis

Conflict of interest: Andrew Bush

  • Received June 14, 2021.
  • Accepted January 5, 2022.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
View Full Text

ERS Members

myERS - ERS members : log in with your myERS username and password.

INDIVIDUALS

Log in Login as an individual user.

Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top
View this article with LENS
Vol 60 Issue 2 Table of Contents
European Respiratory Journal: 60 (2)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Improved prediction of asthma exacerbations by measuring distal airway inflammation
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Improved prediction of asthma exacerbations by measuring distal airway inflammation
Emmanouil Paraskakis, Evangelia Sarikloglou, Sotirios Fouzas, Paschalis Steiropoulos, Aggelos Tsalkidis, Andrew Bush
European Respiratory Journal Jan 2022, 2101684; DOI: 10.1183/13993003.01684-2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Improved prediction of asthma exacerbations by measuring distal airway inflammation
Emmanouil Paraskakis, Evangelia Sarikloglou, Sotirios Fouzas, Paschalis Steiropoulos, Aggelos Tsalkidis, Andrew Bush
European Respiratory Journal Jan 2022, 2101684; DOI: 10.1183/13993003.01684-2021
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Zinc finger protein 33B demonstrates sex-interaction with atopy-related markers in childhood asthma
  • Sensitisation to recombinant Aspergillus fumigatus allergens and clinical outcomes in COPD
  • Impact of COVID-19 social distancing measures on lung transplant recipients: decline in overall respiratory virus infections is associated with stabilisation of lung function
Show more Original research article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society