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Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice

Marija Gredic, Cheng-Yu Wu, Stefan Hadzic, Oleg Pak, Rajkumar Savai, Baktybek Kojonazarov, Siddartha Doswada, Astrid Weiss, Andreas Weigert, Andreas Guenther, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Simone Kraut, Norbert Weissmann
European Respiratory Journal 2021; DOI: 10.1183/13993003.01153-2021
Marija Gredic
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Cheng-Yu Wu
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Stefan Hadzic
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Oleg Pak
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Rajkumar Savai
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
2Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
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  • ORCID record for Rajkumar Savai
Baktybek Kojonazarov
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
3Institute for Lung Health (ILH), Justus-Liebig-University, Giessen, Germany
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Siddartha Doswada
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Astrid Weiss
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Andreas Weigert
4Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany
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Andreas Guenther
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
5European IPF Registry & Biobank (eurIPFreg), Giessen, Germany
6Agaplesion Evangelisches Krankenhaus Mittelhessen, Giessen, Germany
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Ralf P. Brandes
7Faculty of Medicine, Institute for Cardiovascular Physiology, Goethe-University Frankfurt, Frankfurt, Germany
8DZHK – German Center for Cardiovascular Research
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Ralph T. Schermuly
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Friedrich Grimminger
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Werner Seeger
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
2Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
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Natascha Sommer
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Simone Kraut
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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Norbert Weissmann
1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
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  • For correspondence: norbert.weissmann@innere.med.uni-giessen.de
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Article Information

DOI 
https://doi.org/10.1183/13993003.01153-2021
PubMed 
34475225

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received March 19, 2020
  • Accepted August 3, 2021
  • Published online September 2, 2021.

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  • You are currently viewing a previous version of this article (September 2, 2021 - 06:09).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Marija Gredic1,
  2. Cheng-Yu Wu1,
  3. Stefan Hadzic1,
  4. Oleg Pak1,
  5. Rajkumar Savai1,2,
  6. Baktybek Kojonazarov1,3,
  7. Siddartha Doswada1,
  8. Astrid Weiss1,
  9. Andreas Weigert4,
  10. Andreas Guenther1,5,6,
  11. Ralf P. Brandes7,8,
  12. Ralph T. Schermuly1,
  13. Friedrich Grimminger1,
  14. Werner Seeger1,2,
  15. Natascha Sommer1,
  16. Simone Kraut1 and
  17. Norbert Weissmann1⇑
  1. 1Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
  2. 2Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
  3. 3Institute for Lung Health (ILH), Justus-Liebig-University, Giessen, Germany
  4. 4Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany
  5. 5European IPF Registry & Biobank (eurIPFreg), Giessen, Germany
  6. 6Agaplesion Evangelisches Krankenhaus Mittelhessen, Giessen, Germany
  7. 7Faculty of Medicine, Institute for Cardiovascular Physiology, Goethe-University Frankfurt, Frankfurt, Germany
  8. 8DZHK – German Center for Cardiovascular Research
  1. Norbert Weissmann (norbert.weissmann{at}innere.med.uni-giessen.de)
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Funding

  • Deutsche Forschungsgemeinschaft

    Projektnummer 268555672 – SFB 1213, A07 to N.W.; Projektnummer 268555672 – SFB 1213, CP02 to B.K.

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Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice
Marija Gredic, Cheng-Yu Wu, Stefan Hadzic, Oleg Pak, Rajkumar Savai, Baktybek Kojonazarov, Siddartha Doswada, Astrid Weiss, Andreas Weigert, Andreas Guenther, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Simone Kraut, Norbert Weissmann
European Respiratory Journal Jan 2021, 2101153; DOI: 10.1183/13993003.01153-2021

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Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice
Marija Gredic, Cheng-Yu Wu, Stefan Hadzic, Oleg Pak, Rajkumar Savai, Baktybek Kojonazarov, Siddartha Doswada, Astrid Weiss, Andreas Weigert, Andreas Guenther, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Simone Kraut, Norbert Weissmann
European Respiratory Journal Jan 2021, 2101153; DOI: 10.1183/13993003.01153-2021
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