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Dynamics of SARS-CoV-2 shedding in the respiratory depends on the severity of disease in COVID-19 patients

Dieter Munker, Andreas Osterman, Hans Stubbe, Maximilian Muenchhoff, Tobias Veit, Tobias Weinberger, Michaela Barnikel, Jan-Niclas Mumm, Katrin Milger, Elham Khatamzas, Sarah Klauss, Clemens Scherer, Johannes C. Hellmuth, Clemens Giessen-Jung, Michael Zoller, Tobias Herold, Stephanie Stecher, Enrico N. de Toni, Christian Schulz, Nikolaus Kneidinger, Oliver T. Keppler, Jürgen Behr, Julia Mayerle, Stefan Munker
European Respiratory Journal 2021; DOI: 10.1183/13993003.02724-2020
Dieter Munker
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
10contributed equally
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Andreas Osterman
2Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Ludwig Maximilian University, Munich, Germany
3German Center for Infection Research, Partner Site Munich, Munich, Germany and Associated Partner Site Munich, Munich, Germany
10contributed equally
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Hans Stubbe
4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Maximilian Muenchhoff
2Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Ludwig Maximilian University, Munich, Germany
3German Center for Infection Research, Partner Site Munich, Munich, Germany and Associated Partner Site Munich, Munich, Germany
4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
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Tobias Veit
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Tobias Weinberger
6Emergency Department, University Hospital, LMU Munich, Munich, Germany; Department of Medicine 1, Ludwig Maximilian University of Munich (LMU), Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
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Michaela Barnikel
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Jan-Niclas Mumm
7Department of Urology, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Katrin Milger
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Elham Khatamzas
4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
8Department of Medicine 3, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Sarah Klauss
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Clemens Scherer
4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
6Emergency Department, University Hospital, LMU Munich, Munich, Germany; Department of Medicine 1, Ludwig Maximilian University of Munich (LMU), Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
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Johannes C. Hellmuth
4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
8Department of Medicine 3, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Clemens Giessen-Jung
8Department of Medicine 3, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Michael Zoller
9Department of Anaesthesiology, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Tobias Herold
8Department of Medicine 3, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Stephanie Stecher
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Enrico N. de Toni
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Christian Schulz
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Nikolaus Kneidinger
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Oliver T. Keppler
2Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Ludwig Maximilian University, Munich, Germany
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Jürgen Behr
1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Julia Mayerle
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Stefan Munker
5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
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Article Information

DOI 
https://doi.org/10.1183/13993003.02724-2020
PubMed 
33602859

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received July 10, 2020
  • Accepted December 13, 2020
  • Published online February 18, 2021.

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  • You are currently viewing a previous version of this article (February 18, 2021 - 09:51).
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Copyright & Usage 
©The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Dieter Munker1,10,
  2. Andreas Osterman2,3,10,
  3. Hans Stubbe4,5,
  4. Maximilian Muenchhoff2,3,4,
  5. Tobias Veit1,
  6. Tobias Weinberger6,
  7. Michaela Barnikel1,
  8. Jan-Niclas Mumm7,
  9. Katrin Milger1,
  10. Elham Khatamzas4,8,
  11. Sarah Klauss5,
  12. Clemens Scherer4,6,
  13. Johannes C. Hellmuth4,8,
  14. Clemens Giessen-Jung8,
  15. Michael Zoller9,
  16. Tobias Herold8,
  17. Stephanie Stecher5,
  18. Enrico N. de Toni5,
  19. Christian Schulz5,
  20. Nikolaus Kneidinger1,
  21. Oliver T. Keppler2,
  22. Jürgen Behr1,
  23. Julia Mayerle5 and
  24. Stefan Munker5
  1. 1Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
  2. 2Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Ludwig Maximilian University, Munich, Germany
  3. 3German Center for Infection Research, Partner Site Munich, Munich, Germany and Associated Partner Site Munich, Munich, Germany
  4. 4COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany
  5. 5Department of Medicine 2, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
  6. 6Emergency Department, University Hospital, LMU Munich, Munich, Germany; Department of Medicine 1, Ludwig Maximilian University of Munich (LMU), Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
  7. 7Department of Urology, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
  8. 8Department of Medicine 3, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
  9. 9Department of Anaesthesiology, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany
  10. 10contributed equally
  1. Dieter Munker, Department of Medicine 5, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany. E-mail: dieter.munker{at}med.uni-muenchen.de
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Dynamics of SARS-CoV-2 shedding in the respiratory depends on the severity of disease in COVID-19 patients
Dieter Munker, Andreas Osterman, Hans Stubbe, Maximilian Muenchhoff, Tobias Veit, Tobias Weinberger, Michaela Barnikel, Jan-Niclas Mumm, Katrin Milger, Elham Khatamzas, Sarah Klauss, Clemens Scherer, Johannes C. Hellmuth, Clemens Giessen-Jung, Michael Zoller, Tobias Herold, Stephanie Stecher, Enrico N. de Toni, Christian Schulz, Nikolaus Kneidinger, Oliver T. Keppler, Jürgen Behr, Julia Mayerle, Stefan Munker
European Respiratory Journal Jan 2021, 2002724; DOI: 10.1183/13993003.02724-2020

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Dynamics of SARS-CoV-2 shedding in the respiratory depends on the severity of disease in COVID-19 patients
Dieter Munker, Andreas Osterman, Hans Stubbe, Maximilian Muenchhoff, Tobias Veit, Tobias Weinberger, Michaela Barnikel, Jan-Niclas Mumm, Katrin Milger, Elham Khatamzas, Sarah Klauss, Clemens Scherer, Johannes C. Hellmuth, Clemens Giessen-Jung, Michael Zoller, Tobias Herold, Stephanie Stecher, Enrico N. de Toni, Christian Schulz, Nikolaus Kneidinger, Oliver T. Keppler, Jürgen Behr, Julia Mayerle, Stefan Munker
European Respiratory Journal Jan 2021, 2002724; DOI: 10.1183/13993003.02724-2020
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