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Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model

Jan Heyckendorf, Sebastian Marwitz, Maja Reimann, Korkut Avsar, Andrew DiNardo, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan H.E. Kaufmann, Irina Kontsevaya, Frank van Leth, Anna Maria Mandalakas, Florian P. Maurer, Marius Müller, Dörte Nitschkowski, Ioana D. Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Jan Rybniker, Helmut J.F. Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Isabelle Suárez, Elena Terhalle, Markus Unnewehr, January Weiner 3rd, Torsten Goldmann, Christoph Lange
European Respiratory Journal 2021; DOI: 10.1183/13993003.03492-2020
Jan Heyckendorf
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
34Authors contributed equally
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  • ORCID record for Jan Heyckendorf
Sebastian Marwitz
4Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN), Borstel, Germany
5German Center for Lung Research (DZL), Borstel, Germany
34Authors contributed equally
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Maja Reimann
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
34Authors contributed equally
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Korkut Avsar
6Asklepios Fachkliniken München-Gauting, Munich, Germany
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Andrew DiNardo
7The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA
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Gunar Günther
8Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia
9Inselspital Bern, Department of Pulmonology, Bern, Switzerland
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Michael Hoelscher
10Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany
11German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
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Elmira Ibraim
12Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania
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Barbara Kalsdorf
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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Stefan H.E. Kaufmann
13Max Planck Institute for Infection Biology, Berlin, Germany
14Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
15Hagler Institute for Advanced Study, Texas A&M University, College Station, USA
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Irina Kontsevaya
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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Frank van Leth
16Department of Global Health, Amsterdam University Medical Centres, Location AMC, Amsterdam, The Netherlands
17Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands
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Anna Maria Mandalakas
7The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA
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Florian P. Maurer
18National and WHO Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Borstel, Germany
19Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Marius Müller
20Sankt Katharinen-Krankenhaus, Frankfurt, Germany
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Dörte Nitschkowski
4Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN), Borstel, Germany
5German Center for Lung Research (DZL), Borstel, Germany
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Ioana D. Olaru
21London School of Hygiene and Tropical Medicine, London, United Kingdom
22Biomedical Research and Training Institute, Harare, Zimbabwe
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Cristina Popa
12Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania
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Andrea Rachow
10Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany
11German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
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Thierry Rolling
2German Center for Infection Research (DZIF), Borstel, Germany
23Division of Infectious Diseases, I. Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
24Department of Clinical Immunology of Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
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Jan Rybniker
25Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany
26German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
27Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
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Helmut J.F. Salzer
28Department of Pulmonology, Kepler University Hospital, Linz, Austria
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Patricia Sanchez-Carballo
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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Maren Schuhmann
29Universitäts Thoraxklinik-Heidelberg, Heidelberg, Germany
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Dagmar Schaub
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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Victor Spinu
12Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania
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Isabelle Suárez
25Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany
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Elena Terhalle
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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Markus Unnewehr
30Department of Respiratory Medicine and Infectious Diseases, St. Barbara-Klinik, Hamm, Germany
31University of Witten-Herdecke, Witten, Germany
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January Weiner 3rd
32Berlin Institute of HealthCUBI (Core Unit Bioinformatics), Berlin, Germany
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Torsten Goldmann
4Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN), Borstel, Germany
5German Center for Lung Research (DZL), Borstel, Germany
34Authors contributed equally
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Christoph Lange
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
2German Center for Infection Research (DZIF), Borstel, Germany
3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
33Department of Medicine, Karolinska Institute, Stockholm, Sweden
34Authors contributed equally
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Article Information

DOI 
https://doi.org/10.1183/13993003.03492-2020
PubMed 
33574078

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received September 14, 2020
  • Accepted January 20, 2021
  • Published online February 11, 2021.

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  • You are currently viewing a previous version of this article (February 11, 2021 - 09:14).
  • View the most recent version of this article
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©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Jan Heyckendorf1,2,3,34,
  2. Sebastian Marwitz4,5,34,
  3. Maja Reimann1,2,3,34,
  4. Korkut Avsar6,
  5. Andrew DiNardo7,
  6. Gunar Günther8,9,
  7. Michael Hoelscher10,11,
  8. Elmira Ibraim12,
  9. Barbara Kalsdorf1,2,3,
  10. Stefan H.E. Kaufmann13,14,15,
  11. Irina Kontsevaya1,2,3,
  12. Frank van Leth16,17,
  13. Anna Maria Mandalakas7,
  14. Florian P. Maurer18,19,
  15. Marius Müller20,
  16. Dörte Nitschkowski4,5,
  17. Ioana D. Olaru21,22,
  18. Cristina Popa12,
  19. Andrea Rachow10,11,
  20. Thierry Rolling2,23,24,
  21. Jan Rybniker25,26,27,
  22. Helmut J.F. Salzer28,
  23. Patricia Sanchez-Carballo1,2,3,
  24. Maren Schuhmann29,
  25. Dagmar Schaub1,2,3,
  26. Victor Spinu12,
  27. Isabelle Suárez25,
  28. Elena Terhalle1,2,3,
  29. Markus Unnewehr30,31,
  30. January Weiner 3rd32,
  31. Torsten Goldmann4,5,34 and
  32. Christoph Lange1,2,3,33,34
  1. 1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
  2. 2German Center for Infection Research (DZIF), Borstel, Germany
  3. 3International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
  4. 4Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN), Borstel, Germany
  5. 5German Center for Lung Research (DZL), Borstel, Germany
  6. 6Asklepios Fachkliniken München-Gauting, Munich, Germany
  7. 7The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA
  8. 8Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia
  9. 9Inselspital Bern, Department of Pulmonology, Bern, Switzerland
  10. 10Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany
  11. 11German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
  12. 12Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania
  13. 13Max Planck Institute for Infection Biology, Berlin, Germany
  14. 14Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
  15. 15Hagler Institute for Advanced Study, Texas A&M University, College Station, USA
  16. 16Department of Global Health, Amsterdam University Medical Centres, Location AMC, Amsterdam, The Netherlands
  17. 17Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands
  18. 18National and WHO Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Borstel, Germany
  19. 19Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  20. 20Sankt Katharinen-Krankenhaus, Frankfurt, Germany
  21. 21London School of Hygiene and Tropical Medicine, London, United Kingdom
  22. 22Biomedical Research and Training Institute, Harare, Zimbabwe
  23. 23Division of Infectious Diseases, I. Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
  24. 24Department of Clinical Immunology of Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
  25. 25Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany
  26. 26German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
  27. 27Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
  28. 28Department of Pulmonology, Kepler University Hospital, Linz, Austria
  29. 29Universitäts Thoraxklinik-Heidelberg, Heidelberg, Germany
  30. 30Department of Respiratory Medicine and Infectious Diseases, St. Barbara-Klinik, Hamm, Germany
  31. 31University of Witten-Herdecke, Witten, Germany
  32. 32Berlin Institute of HealthCUBI (Core Unit Bioinformatics), Berlin, Germany
  33. 33Department of Medicine, Karolinska Institute, Stockholm, Sweden
  34. 34Authors contributed equally
  1. PD Dr med. Jan Heyckendorf, Medical Clinic, Research Center Borstel, Parkallee 35, 23845 Borstel, Germany. E-mail: jheyckendorf{at}fz-borstel.de
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Funding

  • Deutsche Zentrum für Lungenforschung

  • Deutsches Zentrum für Infektionsforschung

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Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
Jan Heyckendorf, Sebastian Marwitz, Maja Reimann, Korkut Avsar, Andrew DiNardo, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan H.E. Kaufmann, Irina Kontsevaya, Frank van Leth, Anna Maria Mandalakas, Florian P. Maurer, Marius Müller, Dörte Nitschkowski, Ioana D. Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Jan Rybniker, Helmut J.F. Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Isabelle Suárez, Elena Terhalle, Markus Unnewehr, January Weiner, Torsten Goldmann, Christoph Lange
European Respiratory Journal Jan 2021, 2003492; DOI: 10.1183/13993003.03492-2020

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Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
Jan Heyckendorf, Sebastian Marwitz, Maja Reimann, Korkut Avsar, Andrew DiNardo, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan H.E. Kaufmann, Irina Kontsevaya, Frank van Leth, Anna Maria Mandalakas, Florian P. Maurer, Marius Müller, Dörte Nitschkowski, Ioana D. Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Jan Rybniker, Helmut J.F. Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Isabelle Suárez, Elena Terhalle, Markus Unnewehr, January Weiner, Torsten Goldmann, Christoph Lange
European Respiratory Journal Jan 2021, 2003492; DOI: 10.1183/13993003.03492-2020
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