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Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study

Michael R. Loebinger, Eva Polverino, James D. Chalmers, Harm A.W.M. Tiddens, Herman Goossens, Michael Tunney, Felix C. Ringshausen, Adam T. Hill, Rashidkhan Pathan, Gerhild Angyalosi, Francesco Blasi, Stuart J. Elborn, Charles S. Haworth on behalf of the iBEST-1 Trial Team
European Respiratory Journal 2020; DOI: 10.1183/13993003.01451-2020
Michael R. Loebinger
1Host Defence Unit, Royal Brompton Hospital and Harefield NHS Foundation Trust, London, UK
2Imperial College London, London, UK
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Eva Polverino
3Respiratory Disease Department, Vall d’ Hebron University Hospital – VHIR, Barcelona, Spain
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James D. Chalmers
4Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK
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Harm A.W.M. Tiddens
5Department of Paediatric Pulmonology and Allergology, Erasmus Medical Centre Sophia Children's Hospital, Rotterdam, The Netherlands
6Department of Radiology and Nuclear Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
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Herman Goossens
7Department of Clinical Microbiology, University Hospital Antwerp, Antwerp, Belgium
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Michael Tunney
8Halo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK
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  • For correspondence: M.Loebinger@rbht.nhs.uk
Felix C. Ringshausen
9Department of Respiratory Medicine, Hannover Medical School, and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
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  • ORCID record for Felix C. Ringshausen
Adam T. Hill
10Department of Respiratory Medicine, Royal Infirmary of Edinburgh, and University of Edinburgh, Edinburgh, UK
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Rashidkhan Pathan
11Novartis Healthcare Private Limited, Hyderabad, India
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Gerhild Angyalosi
12Novartis Pharma AG, Basel, Switzerland
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Francesco Blasi
13Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
14Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
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Stuart J. Elborn
2Imperial College London, London, UK
15Halo Research Group, Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK
16Imperial College and Royal Brompton Hospital and Harefield NHS Foundation Trust, London, UK
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Charles S. Haworth
17Cambridge Centre for Lung Infection, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK
18Department of Medicine, University of Cambridge, Cambridge, UK
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Article Information

DOI 
https://doi.org/10.1183/13993003.01451-2020
PubMed 
32855225

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received April 28, 2020
  • Accepted July 18, 2020
  • Published online September 9, 2020.

Article Versions

  • previous version (August 27, 2020 - 05:00).
  • You are currently viewing a previous version of this article (September 9, 2020 - 16:05).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©ERS 2020

Author Information

  1. Michael R. Loebinger1,2,
  2. Eva Polverino3,
  3. James D. Chalmers4,
  4. Harm A.W.M. Tiddens5,6,
  5. Herman Goossens7,
  6. Michael Tunney8⇑,
  7. Felix C. Ringshausen9,
  8. Adam T. Hill10,
  9. Rashidkhan Pathan11,
  10. Gerhild Angyalosi12,
  11. Francesco Blasi13,14,
  12. Stuart J. Elborn2,15,16 and
  13. Charles S. Haworth17,18
  14. on behalf of the iBEST-1 Trial Team
  1. 1Host Defence Unit, Royal Brompton Hospital and Harefield NHS Foundation Trust, London, UK
  2. 2Imperial College London, London, UK
  3. 3Respiratory Disease Department, Vall d’ Hebron University Hospital – VHIR, Barcelona, Spain
  4. 4Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK
  5. 5Department of Paediatric Pulmonology and Allergology, Erasmus Medical Centre Sophia Children's Hospital, Rotterdam, The Netherlands
  6. 6Department of Radiology and Nuclear Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
  7. 7Department of Clinical Microbiology, University Hospital Antwerp, Antwerp, Belgium
  8. 8Halo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK
  9. 9Department of Respiratory Medicine, Hannover Medical School, and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
  10. 10Department of Respiratory Medicine, Royal Infirmary of Edinburgh, and University of Edinburgh, Edinburgh, UK
  11. 11Novartis Healthcare Private Limited, Hyderabad, India
  12. 12Novartis Pharma AG, Basel, Switzerland
  13. 13Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
  14. 14Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
  15. 15Halo Research Group, Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK
  16. 16Imperial College and Royal Brompton Hospital and Harefield NHS Foundation Trust, London, UK
  17. 17Cambridge Centre for Lung Infection, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK
  18. 18Department of Medicine, University of Cambridge, Cambridge, UK
  1. Dr Michael R Loebinger, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom. E-mail: M.Loebinger{at}rbht.nhs.uk
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Funding

  • Novartis Foundation

  • Innovative Medicines Initiative

    Inhaled Antibiotics in Bronchiectasis and Cystic F

Article usage

Article usage: August 2020 to March 2021

AbstractFullPdf
Aug 20203822629
Sep 202091596102
Oct 20203515058
Nov 20201993130
Dec 20201642931
Jan 2021988145101
Feb 20211177195174
Mar 20217274135

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Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study
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Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study
Michael R. Loebinger, Eva Polverino, James D. Chalmers, Harm A.W.M. Tiddens, Herman Goossens, Michael Tunney, Felix C. Ringshausen, Adam T. Hill, Rashidkhan Pathan, Gerhild Angyalosi, Francesco Blasi, Stuart J. Elborn, Charles S. Haworth
European Respiratory Journal Jan 2020, 2001451; DOI: 10.1183/13993003.01451-2020

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Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study
Michael R. Loebinger, Eva Polverino, James D. Chalmers, Harm A.W.M. Tiddens, Herman Goossens, Michael Tunney, Felix C. Ringshausen, Adam T. Hill, Rashidkhan Pathan, Gerhild Angyalosi, Francesco Blasi, Stuart J. Elborn, Charles S. Haworth
European Respiratory Journal Jan 2020, 2001451; DOI: 10.1183/13993003.01451-2020
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