Distressing breathlessness at rest | |
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If continuous infusion is available |
Morphine 10 mg + midazolam 10 mg CSCI/ IV over 24 hs OR morphine 5 mg+midazolam 5 mg CSCI/IV over 24 h (if eGFR <30 or in the elderly). In addition, prescribe morphine 2.5 mg+midazolam 2.5 mg SC/IV p.r.n. 4 hourly (1.25 mg for both if eGFR<30 or in the elderly)
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If continuous infusion is not available |
Morphine 2.5 mg SC/IV+midazolam 2.5 mg SC/IV 4 hourly (1.25 mg for both if eGFR<30 or in the elderly). In addition, prescribe morphine 2.5 mg SC/IV+midazolam 2.5 mg SC/IV p.r.n. 4 hourly (1.25 mg for both if eGFR<30 or in the elderly)
Monitor patients receiving opioids for undesirable effects, particularly nausea and vomiting, and constipation. Depending on individual circumstances, prescribe a regular or p.r.n anti-emetic and a regular laxative. |
Anxiety | Mild |
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Moderate/severe |
If needed regularly, consider a CSCI/IV infusion (starting dose midazolam 10 mg /24 h- reduce to 5 mg if eGFR<30 or elderly) |
Cough | | If continuous infusion is available |
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If continuous infusion is not available |
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Monitor patients receiving opioids for undesirable effects, particularly nausea and vomiting, and constipation. Depending on individual circumstances, prescribe a regular or p.r.n anti-emetic and a regular laxative. |
Fever | |
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Delirium | Mild confusion |
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Delirium with distress |
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Delirium/agitation at end of life |
If needed regularly, consider CSCI/IV infusion (either levomepromazine 50 mg or midazolam 15 mg /24 h- reduce to levomepromazine 25 mg or midazolam 7.5 mg (if eGFR<20 or elderly). NB May need to titrate rapidly if ongoing agitation. Where on both opioid and sedative - titrate the sedative up for terminal delirium NOT the opioid |
Communication | Patients |
“I understand that this is an emotional time, anyone would be scared/anxious…it is normal to be worried and scared.” “We do not think recovery from this illness is possible and [you/they] may die over the next [few hours / days / short weeks].” “I am very sorry that you cannot have your loved ones around you, but as you can see, you are here with us, you are not alone, we will stay with you.”
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Family |
“What concerns you the most?” “It's understandable you feel this way / This must be really hard for you / It is upsetting.” “Who is around to support you?” “Is there something we can do to help?” “We are concerned about the condition of your [relative] and think that they are ‘sick enough to die’”
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