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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension

Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes on behalf of The NIHR BioResource – Rare Diseases Consortium, UK PAH Cohort Study Consortium, the US PAH Biobank Consortium
European Respiratory Journal 2019; DOI: 10.1183/13993003.01486-2019
Anna Ulrich
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
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John Wharton
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
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Timothy E. Thayer
2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
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Emilia M. Swietlik
3Department of Medicine, University of Cambridge, Cambridge, United Kingdom
4Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom
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Tufik R. Assad
5Williamson Country Medical Center, Franklin, TN, USA
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Ankit A. Desai
6Indiana University, Indianapolis, IN, USA
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Stefan Gräf
3Department of Medicine, University of Cambridge, Cambridge, United Kingdom
7NIHR BioResource - Rare Diseases, Cambridge, United Kingdom
8Department of Haematology, University of Cambridge, Cambridge, United Kingdom
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  • ORCID record for Stefan Gräf
Lars Harbaum
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
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Marc Humbert
9Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, France
10AP-HP, Service de Pneumologie, Centre de référence de l'hypertension pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
11INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, Paris, France
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Nicholas W. Morrell
3Department of Medicine, University of Cambridge, Cambridge, United Kingdom
7NIHR BioResource - Rare Diseases, Cambridge, United Kingdom
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William C. Nichols
12Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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Florent Soubrier
13Sorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France
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Laura Southgate
14Molecular and Clinical Sciences Research Institute, St George's University of London, London, United Kingdom
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David-Alexandre Trégouët
15INSERM UMR_S 1219, Bordeaux Population Health research center, University of Bordeaux, Bordeaux, France
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Richard C. Trembath
16Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom
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Evan L. Brittain
2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
17Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA
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Martin R. Wilkins
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
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Inga Prokopenko
18Department of Clinical and Experimental Medicine, University of Surrey, Guildford, United Kingdom
19Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
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Christopher J. Rhodes
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
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Article Information

DOI 
https://doi.org/10.1183/13993003.01486-2019
PubMed 
31744833

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received July 25, 2019
  • Accepted October 29, 2019
  • Published online November 19, 2019.

Article Versions

  • You are currently viewing a previous version of this article (November 19, 2019 - 16:05).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©ERS 2019

Author Information

  1. Anna Ulrich1,
  2. John Wharton1,
  3. Timothy E. Thayer2,
  4. Emilia M. Swietlik3,4,
  5. Tufik R. Assad5,
  6. Ankit A. Desai6,
  7. Stefan Gräf3,7,8,
  8. Lars Harbaum1,
  9. Marc Humbert9,10,11,
  10. Nicholas W. Morrell3,7,
  11. William C. Nichols12,
  12. Florent Soubrier13,
  13. Laura Southgate14,
  14. David-Alexandre Trégouët15,
  15. Richard C. Trembath16,
  16. Evan L. Brittain2,17,
  17. Martin R. Wilkins1,
  18. Inga Prokopenko18,19,* and
  19. Christopher J. Rhodes1,*
  20. on behalf of The NIHR BioResource – Rare Diseases Consortium‡
  21. UK PAH Cohort Study Consortium‡
  22. the US PAH Biobank Consortium‡
  1. 1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom
  2. 2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
  3. 3Department of Medicine, University of Cambridge, Cambridge, United Kingdom
  4. 4Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom
  5. 5Williamson Country Medical Center, Franklin, TN, USA
  6. 6Indiana University, Indianapolis, IN, USA
  7. 7NIHR BioResource - Rare Diseases, Cambridge, United Kingdom
  8. 8Department of Haematology, University of Cambridge, Cambridge, United Kingdom
  9. 9Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, France
  10. 10AP-HP, Service de Pneumologie, Centre de référence de l'hypertension pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  11. 11INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, Paris, France
  12. 12Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  13. 13Sorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France
  14. 14Molecular and Clinical Sciences Research Institute, St George's University of London, London, United Kingdom
  15. 15INSERM UMR_S 1219, Bordeaux Population Health research center, University of Bordeaux, Bordeaux, France
  16. 16Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom
  17. 17Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA
  18. 18Department of Clinical and Experimental Medicine, University of Surrey, Guildford, United Kingdom
  19. 19Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
  1. Mr Christopher J. Rhodes, National Heart and Lung Institute, Medicine, Imperial College London, London, W12 0NN, United Kingdom. E-mail: crhodes{at}imperial.ac.uk
  1. ↵‡ Members listed in the appendix

  2. ↵* These authors contributed equally to this study

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Funding

  • NIH

    HL105333; HL146588; R01HL136603; S10RR025141
  • German Ministry for Education and Research

    01EY1103
  • CTSA

    UL1RR024975; UL1TR000445; UL1TR002243
  • American Heart Association

    13FTF16070002
  • Deutsche Forschungsgemeinschaft

    SFB1213, project A09
  • DYNAHealth

    633595
  • Wellcome Trust

    204809/Z/16/Z; WT205915
  • UK Medical Research Council

    MR/K020919/1
  • British Heart Foundation

    FS/15/59/31839; RG/08/006/25302; RG/10/16/28575; RG/13/4/30107; SP/12/12/29836

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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension
Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
European Respiratory Journal Jan 2019, 1901486; DOI: 10.1183/13993003.01486-2019

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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension
Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
European Respiratory Journal Jan 2019, 1901486; DOI: 10.1183/13993003.01486-2019
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