Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Effect of asthma exacerbation during pregnancy in women with asthma: A population-based cohort study

Kawsari Abdullah, Jingqin Zhu, Andrea Gershon, Sharon Dell, Teresa To
European Respiratory Journal 2019; DOI: 10.1183/13993003.01335-2019
Kawsari Abdullah
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
2Emergency Medicine, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: KAbdullah@cheo.on.ca
Jingqin Zhu
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrea Gershon
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
3ICES, Toronto, Canada
4Division of respirology, Sunnybrook Health Sciences Centre, Toronto, Canada
5Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
6Department of Medicine, University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrea Gershon
Sharon Dell
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
5Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
7Respiratory Medicine, The Hospital for Sick Children, Toronto, Canada
8Department of Paediatrics, University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Teresa To
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
3ICES, Toronto, Canada
5Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The association between asthma exacerbation (AE) during pregnancy and adverse maternal and child health outcomes have not been appropriately investigated. Our objective was to determine the short- and long-term intergenerational effect of AE in pregnant women with asthma.

A population cohort study was conducted using data from the Ontario asthma surveillance system and population-level health administrative data. AE in pregnant women with asthma was defined as at least one of the following criteria: ≥5 physician visits, or 1 emergency department visit, or 1 hospital admission for asthma during pregnancy. Pregnancy complications, adverse perinatal outcomes, and early childhood respiratory disorders were identified using ICD codes 9th and 10th Revisions.

The cohort consisted of 103 424 singleton pregnancies in women with asthma. AE in pregnant women with asthma was associated with higher odds of preeclampsia (OR 1.30; 95% CI 1.12, 1.51), and pregnancy induced hypertension (OR 1.17; 95% CI 1.02, 1.33); babies had higher odds of low birth weight (OR 1.14; 95% CI 1.00, 1.31), being pre-term (OR 1.14; 95% CI 1.01, 1.29), and congenital malformations (OR 1.21; 95% CI 1.05, 1.39). Children born to women with AE during pregnancy had elevated risk of asthma (OR 1.23; 95% CI 1.13, 1.33) and pneumonia (OR 1.12; 95% CI 1.03, 1.22) during first 5 years of life.

AE during pregnancy in women with asthma showed increased risk of pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders in their children, indicating appropriate asthma management may reduce the risk of adverse health outcomes.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Abdullah has nothing to disclose.

Conflict of interest: Zhu has nothing to disclose.

Conflict of interest: Dr. Gershon has nothing to disclose.

Conflict of interest: Dr. Dell has nothing to disclose.

Conflict of interest: Dr. To has nothing to disclose.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received July 5, 2019.
  • Accepted October 24, 2019.
  • Copyright ©ERS 2019
PreviousNext
Back to top
View this article with LENS
Vol 61 Issue 2 Table of Contents
European Respiratory Journal: 61 (2)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect of asthma exacerbation during pregnancy in women with asthma: A population-based cohort study
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Effect of asthma exacerbation during pregnancy in women with asthma: A population-based cohort study
Kawsari Abdullah, Jingqin Zhu, Andrea Gershon, Sharon Dell, Teresa To
European Respiratory Journal Jan 2019, 1901335; DOI: 10.1183/13993003.01335-2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Effect of asthma exacerbation during pregnancy in women with asthma: A population-based cohort study
Kawsari Abdullah, Jingqin Zhu, Andrea Gershon, Sharon Dell, Teresa To
European Respiratory Journal Jan 2019, 1901335; DOI: 10.1183/13993003.01335-2019
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
  • Info & Metrics
  • PDF

Subjects

  • Asthma and allergy
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Lung volumes and survival in chronic lung allograft dysfunction
  • Safety of formoterol in asthma clinical trials
  • Second-line therapy in elderly patients with advanced NSCLC
Show more Original article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society