Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
Xiao-Jian Wang, Tian-Yu Lian, Xin Jiang, Shao-Fei Liu, Su-Qi Li, Rong Jiang, Wen-Hui Wu, Jue Ye, Chun-Yan Cheng, Yao Du, Xi-Qi Xu, Yan Wu, Fu-Hua Peng, Kai Sun, Yi-Min Mao, Huan Yu, Chen Liang, John Y-J. Shyy, Shu-Yang Zhang, Xue Zhang, Zhi-Cheng Jing
European Respiratory Journal 2018; DOI: 10.1183/13993003.01609-2018
Xiao-Jian Wang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Tian-Yu Lian
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Xin Jiang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Shao-Fei Liu
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Su-Qi Li
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Rong Jiang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Wen-Hui Wu
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Jue Ye
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Chun-Yan Cheng
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Yao Du
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Xi-Qi Xu
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Yan Wu
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Fu-Hua Peng
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Kai Sun
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Yi-Min Mao
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Huan Yu
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Chen Liang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
John Y-J. Shyy
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Shu-Yang Zhang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Xue Zhang
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
Zhi-Cheng Jing
From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).

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- Xiao-Jian Wang,
- Tian-Yu Lian,
- Xin Jiang,
- Shao-Fei Liu,
- Su-Qi Li,
- Rong Jiang,
- Wen-Hui Wu,
- Jue Ye,
- Chun-Yan Cheng,
- Yao Du,
- Xi-Qi Xu,
- Yan Wu,
- Fu-Hua Peng,
- Kai Sun,
- Yi-Min Mao,
- Huan Yu,
- Chen Liang,
- John Y-J. Shyy,
- Shu-Yang Zhang,
- Xue Zhang and
- Zhi-Cheng Jing
- From the Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College (X.-J.W., X.J., T.-Y.L., S.-F.L., S.-Q.L., J.Y., C.-Y.C., Y.D., X.-Q.X., Y.W., F.-H.P., K.S., Z.-C.J.); Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (W.-H.W., R.J.); Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (Y.-M.M.); Novogene Co., Ltd., Beijing, China (H.Y., C.L.); Department of Medicine, University of California, San Diego, La Jolla, California, USA (J.S.); Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China (S.-Y. Z.) and McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z.).
- Zhi-Cheng Jing, Key Laboratory of Pulmonary Vascular Medicine & FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy Medical Sciences & Peking Union Medical College, No. 167, Beilishi Road, Beijing, 100037, China. E-mail: jingzhicheng{at}vip.163.com
Funding
National Key Research and Development Program of China
2016YFC0901502National Science Fund for Distinguished Young Scholars
81425002National Natural Science Foundation of China
81320108005; 81630003; 81670052Director Fund from State Key Laboratory of Cardiovascular Disease
2017ZR-03; 2018ZR-02Natural Science Foundation of Beijing Municipality
7172180; 7181009Chinese Academy of Medical Sciences
2016-I2M-1-002; 2016-I2M-4-003
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Vol 61 Issue 2
Table of Contents
Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
Xiao-Jian Wang, Tian-Yu Lian, Xin Jiang, Shao-Fei Liu, Su-Qi Li, Rong Jiang, Wen-Hui Wu, Jue Ye, Chun-Yan Cheng, Yao Du, Xi-Qi Xu, Yan Wu, Fu-Hua Peng, Kai Sun, Yi-Min Mao, Huan Yu, Chen Liang, John Y-J. Shyy, Shu-Yang Zhang, Xue Zhang, Zhi-Cheng Jing
European Respiratory Journal Jan 2018, 1801609; DOI: 10.1183/13993003.01609-2018
Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
Xiao-Jian Wang, Tian-Yu Lian, Xin Jiang, Shao-Fei Liu, Su-Qi Li, Rong Jiang, Wen-Hui Wu, Jue Ye, Chun-Yan Cheng, Yao Du, Xi-Qi Xu, Yan Wu, Fu-Hua Peng, Kai Sun, Yi-Min Mao, Huan Yu, Chen Liang, John Y-J. Shyy, Shu-Yang Zhang, Xue Zhang, Zhi-Cheng Jing
European Respiratory Journal Jan 2018, 1801609; DOI: 10.1183/13993003.01609-2018