Abstract
Perinatal exposure to ambient air pollution has been associated with childhood asthma incidence, however, less is known regarding the potential effect modifiers in this association. We examined whether maternal and infant characteristics modified the association between perinatal exposure to air pollution and development of childhood asthma.
761 172 births occurring between 2006 and 2012 were identified in the province of Ontario, Canada. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using Cox regression models.
110,981 children with asthma were identified. In models adjusted for postnatal exposures, second trimester exposures to particulate matter with a diameter ≤2.5 μm (PM2.5) (Hazard Ratio (HR) per interquartile (IQR) increase=1.07, 95% CI: 1.06–1.09) and nitrogen dioxide (NO2) (HR per IQR increase=1.06, 95% CI: 1.03–1.08) were associated with childhood asthma development. Enhanced impacts were found among children born to mothers with asthma, those who smoked during pregnancy, boys, those born preterm, of low birth weight and among those born to mothers living in urban areas during pregnancy.
Prenatal exposure to air pollution may have a differential impact on the risk of asthma development according to maternal and infant characteristics.
Abstract
Maternal asthma enhances the effect of air pollution during pregnancy on the risk of developing asthma in children
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Lavigne has nothing to disclose.
Conflict of interest: Marc-André Belair
Conflict of interest: Daniel Rodriguez Duque
Conflict of interest: Minh T. Do
Conflict of interest: David M. Stieb
Conflict of interest: Perry Hystad
Conflict of interest: Aaron van Donkelaar
Conflict of interest: Randall V. Martin
Conflict of interest: Daniel L. Crouse
Conflict of interest: Eric Crighton
Conflict of interest: Hong Chen
Conflict of interest: Richard T. Burnett
Conflict of interest: Scott Weichenthal
Conflict of interest: Paul J. Villeneuve
Conflict of interest: Teresa To
Conflict of interest: Jeffrey R. Brook
Conflict of interest: Markey Johnson
Conflict of interest: Sabit Cakmak
Conflict of interest: Abdool S. Yasseen
Conflict of interest: Mark Walker
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