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Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, Margaux Sanchez, Andrea Vierkötter, Alessandro Marcon, Dirk Keidel, Dorothee Sugiri, Zaina Al Kanani, Rachel Nadif, Valérie Siroux, Rebecca Hardy, Diana Kuh, Thierry Rochat, Pierre-Olivier Bridevaux, Marloes Eeftens, Ming-Yi Tsai, Simona Villani, Harish Chandra Phuleria, Matthias Birk, Josef Cyrys, Marta Cirach, Audrey de Nazelle, Mark J. Nieuwenhuijsen, Bertil Forsberg, Kees de Hoogh, Christophe Declerq, Roberto Bono, Pavilio Piccioni, Ulrich Quass, Joachim Heinrich, Deborah Jarvis, Isabelle Pin, Rob Beelen, Gerard Hoek, Bert Brunekreef, Christian Schindler, Jordi Sunyer, Ursula Krämer, Francine Kauffmann, Anna L. Hansell, Nino Künzli, Nicole Probst-Hensch
European Respiratory Journal 2014; DOI: 10.1183/09031936.00130014
Martin Adam
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
27These authors contributed equally
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Tamara Schikowski
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
3Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf
27These authors contributed equally
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Anne Elie Carsin
4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
27These authors contributed equally
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Yutong Cai
5MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
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Benedicte Jacquemin
4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
6Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif
7Univ. Paris-Sud, UMRS 1018, Villejuif
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Margaux Sanchez
6Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif
7Univ. Paris-Sud, UMRS 1018, Villejuif
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Andrea Vierkötter
3Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf
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Alessandro Marcon
8Unit of Epidemiology and Medical Statistics, Dept of Public Health and Community Medicine, University of Verona, Verona
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Dirk Keidel
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
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Dorothee Sugiri
3Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf
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Zaina Al Kanani
5MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
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Rachel Nadif
6Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif
7Univ. Paris-Sud, UMRS 1018, Villejuif
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Valérie Siroux
9Inserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble
10Univ. Joseph Fourier, Grenoble
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Rebecca Hardy
11MRC University Unit for Lifelong Health and Ageing, University College London, London
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Diana Kuh
11MRC University Unit for Lifelong Health and Ageing, University College London, London
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Thierry Rochat
12Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland
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Pierre-Olivier Bridevaux
12Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland
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Marloes Eeftens
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
13Institute for Risk Assessment Sciences, Utrecht University, Utrecht
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Ming-Yi Tsai
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
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Simona Villani
14Unit of Biostatistics and Clinical Epidemiology Dept of Public Health, Experimental and Forensic Medicine University of Pavia, Pavia
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Harish Chandra Phuleria
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
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Matthias Birk
15Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg
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Josef Cyrys
15Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg
16Environmental Science Center, University Augsburg, Augsburg
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Marta Cirach
4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
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Audrey de Nazelle
17Centre for Environmental Policy, Imperial College London, London
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Mark J. Nieuwenhuijsen
4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
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Bertil Forsberg
18Environmental and Occupational Medicine, Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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Kees de Hoogh
5MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
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Christophe Declerq
19French Institute for Public Health Surveillance, Saint-Maurice
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Roberto Bono
20Dept of Public Health and Pediatrics, University of Turin, Turin
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Pavilio Piccioni
21SC Pneumologia CPA ASL 4 Turin, Turin, Italy
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Ulrich Quass
22Air Quality and Sustainable Nanotechnology, IUTA Institut für Energie- und Umwelttechnik e.V., Duisburg, Germany
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Joachim Heinrich
15Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg
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Deborah Jarvis
5MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
23Dept of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London
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Isabelle Pin
9Inserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble
10Univ. Joseph Fourier, Grenoble
24Pédiatrie, CHU de Grenoble, La Tronche, France
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Rob Beelen
13Institute for Risk Assessment Sciences, Utrecht University, Utrecht
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Gerard Hoek
13Institute for Risk Assessment Sciences, Utrecht University, Utrecht
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Bert Brunekreef
13Institute for Risk Assessment Sciences, Utrecht University, Utrecht
25Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
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Christian Schindler
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
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Jordi Sunyer
4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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Ursula Krämer
3Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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Francine Kauffmann
6Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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Anna L. Hansell
5MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
26Public Health and Primary Care Directorate, Imperial College Healthcare NHS Trust, London, UK
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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Nino Künzli
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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Nicole Probst-Hensch
1Swiss Tropical and Public Health Institute, Basel
2University of Basel, Basel
28Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
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  • For correspondence: Nicole.Probst@unibas.ch
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Abstract

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE).

Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis.

We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95%CI −25.8– −2.1) and FVC (−14.9 mL, 95% CI −28.7– −1.1). An increase of 10 μg·m−3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (−44.6 mL, 95% CI −85.4– −3.8) and FVC (−59.0 mL, 95% CI −112.3– −5.6). The associations were particularly strong in obese persons.

This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.

Abstract

The ESCAPE study finds that, even at very low levels, air pollution has adverse effects on lung function in adults http://ow.ly/A1ssB

  • Received July 16, 2014.
  • Accepted July 24, 2014.
  • ©ERS
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Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, Margaux Sanchez, Andrea Vierkötter, Alessandro Marcon, Dirk Keidel, Dorothee Sugiri, Zaina Al Kanani, Rachel Nadif, Valérie Siroux, Rebecca Hardy, Diana Kuh, Thierry Rochat, Pierre-Olivier Bridevaux, Marloes Eeftens, Ming-Yi Tsai, Simona Villani, Harish Chandra Phuleria, Matthias Birk, Josef Cyrys, Marta Cirach, Audrey de Nazelle, Mark J. Nieuwenhuijsen, Bertil Forsberg, Kees de Hoogh, Christophe Declerq, Roberto Bono, Pavilio Piccioni, Ulrich Quass, Joachim Heinrich, Deborah Jarvis, Isabelle Pin, Rob Beelen, Gerard Hoek, Bert Brunekreef, Christian Schindler, Jordi Sunyer, Ursula Krämer, Francine Kauffmann, Anna L. Hansell, Nino Künzli, Nicole Probst-Hensch
European Respiratory Journal Jan 2014, erj01300-2014; DOI: 10.1183/09031936.00130014

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Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, Margaux Sanchez, Andrea Vierkötter, Alessandro Marcon, Dirk Keidel, Dorothee Sugiri, Zaina Al Kanani, Rachel Nadif, Valérie Siroux, Rebecca Hardy, Diana Kuh, Thierry Rochat, Pierre-Olivier Bridevaux, Marloes Eeftens, Ming-Yi Tsai, Simona Villani, Harish Chandra Phuleria, Matthias Birk, Josef Cyrys, Marta Cirach, Audrey de Nazelle, Mark J. Nieuwenhuijsen, Bertil Forsberg, Kees de Hoogh, Christophe Declerq, Roberto Bono, Pavilio Piccioni, Ulrich Quass, Joachim Heinrich, Deborah Jarvis, Isabelle Pin, Rob Beelen, Gerard Hoek, Bert Brunekreef, Christian Schindler, Jordi Sunyer, Ursula Krämer, Francine Kauffmann, Anna L. Hansell, Nino Künzli, Nicole Probst-Hensch
European Respiratory Journal Jan 2014, erj01300-2014; DOI: 10.1183/09031936.00130014
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