Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Nitrogen dioxide and mortality: review and meta-analysis of long-term studies

Annunziata Faustini, Regula Rapp, Francesco Forastiere
European Respiratory Journal 2014; DOI: 10.1183/09031936.00114713
Annunziata Faustini
1Dept of Epidemiology, Regional Health Service, Lazio Region, Rome, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Regula Rapp
2Swiss Tropical and Public Health Institute, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesco Forastiere
1Dept of Epidemiology, Regional Health Service, Lazio Region, Rome, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Exposure to ambient nitrogen dioxide (NO2) has been linked to increased mortality in several epidemiological studies but the question remains of whether NO2 is directly responsible for the health effects or is only an indicator of other pollutants, including particulate matter. The aim of the present review was to provide pooled estimates of the long-term effects of NO2 on mortality, which are potentially useful for health impact assessment.

We selected 23 papers, published from 2004 to 2013, evaluating the relationship between NO2 and mortality, also including an assessment of the effect of particulate matter exposure. A random-effects meta-analysis was carried out on 19 studies.

The pooled effect on mortality was 1.04 (95% CI 1.02–1.06) with an increase of 10 μg·m−3 in the annual NO2 concentration and 1.05 (95% CI 1.01–1.09) for particulate matter <2.5 μm in diameter (PM2.5) (10 μg·m−3). The effect on cardiovascular mortality was 1.13 (95% CI 1.09–1.18) for NO2 and 1.20 (95% CI 1.09–1.31) for PM2.5. The NO2 effect on respiratory mortality was 1.03 (95% CI 1.02–1.03) and 1.05 (95% CI 1.01–1.09) for PM2.5. Four bipollutant analyses with particulate matter and NO2 in the same models showed minimal changes in the effect estimates of NO2.

There is evidence of a long-term effect of NO2 on mortality as great as that of PM2.5. An independent effect of NO2 emerged from multipollutant models.

Abstract

Any health impact assessment overlooking NO2 would neglect some adverse effects of today’s air pollution mixture http://ow.ly/sPKsR

  • Received July 5, 2013.
  • Accepted December 19, 2013.
  • © ERS
Next
Back to top
Vol 61 Issue 6 Table of Contents
European Respiratory Journal: 61 (6)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Nitrogen dioxide and mortality: review and meta-analysis of long-term studies
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Nitrogen dioxide and mortality: review and meta-analysis of long-term studies
Annunziata Faustini, Regula Rapp, Francesco Forastiere
European Respiratory Journal Jan 2014, erj01147-2013; DOI: 10.1183/09031936.00114713

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Nitrogen dioxide and mortality: review and meta-analysis of long-term studies
Annunziata Faustini, Regula Rapp, Francesco Forastiere
European Respiratory Journal Jan 2014, erj01147-2013; DOI: 10.1183/09031936.00114713
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • The path to TB Elimination: a renewed vision
  • The paradox of immune checkpoint inhibition re-activating tuberculosis
  • The physiological basis of pulmonary arterial hypertension
Show more Review

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society