Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung, Sally E Wenzel, Jan L Brozek, Andrew Bush, Mario Castro, Peter J Sterk, Ian M Adcock, Eric D Bateman, Elisabeth H Bel, Eugene R Bleecker, Louis-Philippe Boulet, Christopher Brightling, Pascal Chanez, Sven-Erik Dahlen, Ratko Djukanovic, Urs Frey, Mina Gaga, Peter Gibson, Qutayba Hamid, Nizar N Jajour, Thais Mauad, Ronald L Sorkness, W Gerald Teague
European Respiratory Journal 2013; DOI: 10.1183/09031936.00202013
Kian Fan Chung
*Kian Fan Chung, National Heart & Lung Institute, Imperial College & Biomedical Research Unit, Royal Brompton Hospital, London, UK
ffffKFC and SEW contributed equally to this document
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: f.chung@imperial.ac.uk
Sally E Wenzel
#Sally E Wenzel, University of Pittsburgh, Pittsburgh, PA, USA
ffffKFC and SEW contributed equally to this document
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan L Brozek
¶Jan L Brozek, Dept of Clinical Epidemiology & Biostatistics & Medicine, McMaster University, Hamilton, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Bush
+Andrew Bush, National Heart & Lung Institute, Imperial College & Biomedical Research Unit, Royal Brompton Hospital, London SW3, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario Castro
§Mario Castro, Washington University, St Louis, MO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter J Sterk
fPeter J Sterk, Dept of Respiratory Medicine, Academic Medical Centre, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian M Adcock
**Ian M Adcock, National Heart & Lung Institute, Imperial College, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric D Bateman
##Eric D Bateman, University of Cape Town, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elisabeth H Bel
¶¶Elisabeth H Bel, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eugene R Bleecker
++Eugene R Bleecker, Wake Forest University, Winston Salem, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Louis-Philippe Boulet
§§Louis-Philippe Boulet, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Brightling
ffChristopher Brightling, Institute for Lung Health, Leicester University, Leicester, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pascal Chanez
***Pascal Chanez, Departement des Maladies Respiratoires, Marseille Universite, Marseille, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sven-Erik Dahlen
###Sven-Erik Dahlen, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ratko Djukanovic
¶¶¶Ratko Djukanovic, Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton School of Medicine & Southampton General Hospital, Southampton UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Urs Frey
+++Urs Frey, University Children's Hospital (UKBB), University of Basel, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mina Gaga
§§§Mina Gaga, 7th Respiratory Dept and Asthma Centre, Athens Chest Hospital, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Gibson
fffPeter Gibson, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qutayba Hamid
****Qutayba Hamid, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nizar N Jajour
####Nizar N Jarjour, University of Wisconsin, Madison, WI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thais Mauad
¶¶¶¶Thais Mauad, University Medical School, Sao Paulo, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ronald L Sorkness
++++Ronald L Sorkness, University of Wisconsin, Madison, WI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W Gerald Teague
§§§§W Gerald Teague, Division of Respiratory Medicine, Allergy, and Immunology, Dept of Paediatrics, University of Virginia School of Medicine, VA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

This article has a correction. Please see:

  • “International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.” Kian Fan Chung, Sally E. Wenzel, Jan L. Brozek, Andrew Bush, Mario Castro, Peter J. Sterk, Ian M. Adcock, Eric D. Bateman, Elisabeth H. Bel, Eugene R. Bleecker, Louis-Philippe Boulet, Christopher Brightling, Pascal Chanez, Sven-Erik Dahlen, Ratko Djukanovic, Urs Frey, Mina Gaga, Peter Gibson, Qutayba Hamid, Nizar N. Jajour, Thais Mauad, Ronald L. Sorkness and W. Gerald Teague. Eur Respir J 2014; 43: 343–373. - July 01, 2018

Abstract

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need.

Supported by the American Thoracic Society (ATS) and European Respiratory Society (ERS), a Task Force reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults.

We performed a literature review followed by discussion by an expert committee according to the GRADE approach to develop specific clinical recommendations.

When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming “uncontrolled” or that remains “uncontrolled“ despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided.

Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.

  • Difficult-to-treat asthma
  • GRADE practice guidelines
  • severe asthma
  • therapy resistant asthma
  • ERS
Next
Back to top
Vol 57 Issue 3 Table of Contents
European Respiratory Journal: 57 (3)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung, Sally E Wenzel, Jan L Brozek, Andrew Bush, Mario Castro, Peter J Sterk, Ian M Adcock, Eric D Bateman, Elisabeth H Bel, Eugene R Bleecker, Louis-Philippe Boulet, Christopher Brightling, Pascal Chanez, Sven-Erik Dahlen, Ratko Djukanovic, Urs Frey, Mina Gaga, Peter Gibson, Qutayba Hamid, Nizar N Jajour, Thais Mauad, Ronald L Sorkness, W Gerald Teague
European Respiratory Journal Jan 2013, erj02020-2013; DOI: 10.1183/09031936.00202013

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung, Sally E Wenzel, Jan L Brozek, Andrew Bush, Mario Castro, Peter J Sterk, Ian M Adcock, Eric D Bateman, Elisabeth H Bel, Eugene R Bleecker, Louis-Philippe Boulet, Christopher Brightling, Pascal Chanez, Sven-Erik Dahlen, Ratko Djukanovic, Urs Frey, Mina Gaga, Peter Gibson, Qutayba Hamid, Nizar N Jajour, Thais Mauad, Ronald L Sorkness, W Gerald Teague
European Respiratory Journal Jan 2013, erj02020-2013; DOI: 10.1183/09031936.00202013
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • Asthma and allergy
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Task Force report: European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis
  • Imaging of pulmonary hypertension: Fleischner Society position paper
  • ERS Statement on Chronic Thromboembolic Pulmonary Hypertension
Show more Task force report

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society