Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions

Asthma affects time to pregnancy and fertility: a register-based twin study

Elisabeth Juul Gade, SF Thomsen, S Lindenberg, K.O. Kyvik, S Lieberoth, V Backer
European Respiratory Journal 2013; DOI: 10.1183/09031936.00148713
Elisabeth Juul Gade
*Respiratory Research Unit, Bispebjerg University hospital, Copenhagen, Denmark
#Copenhagen Fertility Center, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Elisabeth_gade@yahoo.com
SF Thomsen
*Respiratory Research Unit, Bispebjerg University hospital, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S Lindenberg
#Copenhagen Fertility Center, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K.O. Kyvik
¶The Danish twin registry, Institute for Health and Service Research, Odense, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S Lieberoth
*Respiratory Research Unit, Bispebjerg University hospital, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
V Backer
*Respiratory Research Unit, Bispebjerg University hospital, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Coexistence of infertility and asthma has been observed clinically. We therefore investigated the association between asthma and delayed pregnancy in a nationwide population-based cohort of twins.

A cohort of 15250 twins living in Denmark (aged 12–41 years) participated in a questionnaire study including questions about the presence of asthma and fertility. Differences in time to pregnancy and pregnancy outcome were analysed in subjects with asthma, allergy and in healthy individuals using multiple regression analysis.

Asthma was associated with increased time to pregnancy 27% vs. 21.6%, OR=1.31 (1.1–1.6), p=0.009. The association remained significant after adjustment for age, age at menarche, BMI and socioeconomic status (p=0.05 OR=1.25(1–1.6)), and was more pronounced in those above 30 years of age (32.2% vs. 24.9% p=0.04 OR=1.44 (1.1–1.9)). Untreated asthmatics had significant increased risk of prolonged TTP compared to healthy individuals (OR=1.79 (1.2–2.66) p=0.004), while asthmatics receiving any kind of treatment for asthma trended having a shorter TTP than untreated asthmatics (OR=1.40, p=0.134).

Asthma prolongs time to pregnancy. The negative effect of asthma on fertility increases with age and is growing with disease intensity, indicating that a systemic disease characterized by systemic inflammation also can involve reproductive processes.

  • Asthma
  • allergy
  • infertility
  • time to pregnancy
  • pregnancy outcome
  • twin studies
  • ERS
Next
Back to top
Vol 61 Issue 2 Table of Contents
European Respiratory Journal: 61 (2)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Asthma affects time to pregnancy and fertility: a register-based twin study
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Asthma affects time to pregnancy and fertility: a register-based twin study
Elisabeth Juul Gade, SF Thomsen, S Lindenberg, K.O. Kyvik, S Lieberoth, V Backer
European Respiratory Journal Jan 2013, erj01487-2013; DOI: 10.1183/09031936.00148713

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Asthma affects time to pregnancy and fertility: a register-based twin study
Elisabeth Juul Gade, SF Thomsen, S Lindenberg, K.O. Kyvik, S Lieberoth, V Backer
European Respiratory Journal Jan 2013, erj01487-2013; DOI: 10.1183/09031936.00148713
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF

Subjects

  • Asthma and allergy
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Lung volumes and survival in chronic lung allograft dysfunction
  • Prediction of new-onset asthma and nasal allergy
  • Mortality and causes of death in HIV/tuberculosis patients
Show more Original article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society