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Reduced neonatal lung function and wheezing illnesses during the first five years of life

Anne C. van der Gugten, Cuno S.P.M. Uiterwaal, Nienke van Putte-Katier, Marije Koopman, Theo J.M. Verheij, Cornelis K. van der Ent
European Respiratory Journal 2012; DOI: 10.1183/09031936.00214711
Anne C. van der Gugten
*Dept of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
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  • For correspondence: a.c.vandergugten@umcutrecht.nl
Cuno S.P.M. Uiterwaal
#Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
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Nienke van Putte-Katier
*Dept of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
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Marije Koopman
*Dept of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
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Theo J.M. Verheij
#Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
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Cornelis K. van der Ent
*Dept of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
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Abstract

Studies about reduced neonatal lung function and wheezing illnesses during childhood showed conflicting results. The aim of this study was to assess the association between resistance and compliance of the respiratory system (Rrs/Crs) by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort.

SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file.

549 infants had successful SOT measurement and complete medical records. Every kPa·l−1·s−1 increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa−1 increase in Crs was associated with a 14% reduction of consultations in the first 3 years of life, 27% in the 4th-5th year of life, and a lower probability of having asthma at the age of 5 (OR=0.66). Children with late-onset or persistent wheezing had significant lower Crs values than their peers.

An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma.

  • Asthma
  • infants
  • wheezing phenotype
  • ERS
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European Respiratory Journal: 61 (1)
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Reduced neonatal lung function and wheezing illnesses during the first five years of life
Anne C. van der Gugten, Cuno S.P.M. Uiterwaal, Nienke van Putte-Katier, Marije Koopman, Theo J.M. Verheij, Cornelis K. van der Ent
European Respiratory Journal Jan 2012, erj02147-2011; DOI: 10.1183/09031936.00214711

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Reduced neonatal lung function and wheezing illnesses during the first five years of life
Anne C. van der Gugten, Cuno S.P.M. Uiterwaal, Nienke van Putte-Katier, Marije Koopman, Theo J.M. Verheij, Cornelis K. van der Ent
European Respiratory Journal Jan 2012, erj02147-2011; DOI: 10.1183/09031936.00214711
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