Cftr biomarkers: time for promotion to surrogate endpoint?
K. De Boeck, L Kent, J Davies, N Derichs, M Amaral, SM Rowe, P Middleton, H de Jonge, I Bronsveld, M Wilschanski, P Melotti, I Danner-Boucher, S Boerner, I Fajac, K Southern, RA de Nooijer, A Bot, Y de Rijke, E de Wachter, T Leal, F Vermeulen, M J Hug, G Rault, T Nguyen-Khoa, C Barreto, M Proesmans, I Sermet-Gaudelus On behalf of the European Cystic Fibrosis Society Clinical Trial Network Standardisation Committee
European Respiratory Journal 2012; DOI: 10.1183/09031936.00057512
K. De Boeck
*University Hospital of Leuven, Leuven, Belgium
L Kent
#University of Ulster, Belfast, UK
¶Belfast Health and Social Care Trust, Belfast, UK
J Davies
+Dept of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK
N Derichs
§CFTR Biomarker Centre & Cystic Fibrosis Centre, Dept of Paediatric Pulmonology and Immunology, Charité University Berlin, Germany
M Amaral
fCentre for Human Genetics, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal
**Dept of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, Lisbon, Portugal
SM Rowe
##Dept of Medicine, University of Alabama, Birmingham, USA
P Middleton
¶¶Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, NSW, Australia
H de Jonge
++Depts of Paediatric Gastroenterology and Biochemistry, Erasmus University Medical Centre, Rotterdam, The Netherlands
I Bronsveld
§§University Medical Centre, Utrecht, The Netherlands
M Wilschanski
ffHadassah University Hospitals, Hebrew University Medical School, Jerusalem, Israel
P Melotti
***Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
I Danner-Boucher
###Laboratoire des Explorations Fonctionnelles and Service de Pneumologie, Hôpital G & R Laënnec, Nantes, France
S Boerner
¶¶¶CF Center Cologne, University of Cologne, Germany
I Fajac
+++Service d'Explorations Fonctionnelles, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
K Southern
§§§Dept of Women's and Children's Health, University of Liverpool, UK
RA de Nooijer
fffUniversity Medical Centre, Utrecht, The Netherlands
A Bot
****Dept of Biochemistry, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
Y de Rijke
####Dept of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
E de Wachter
¶¶¶¶Dept of Pediatric Pulmonology and CF-Clinic, Universitair Ziekenhuis Brussel, Brussels, Belgium
T Leal
++++Clinical Chemistry, Université Catholique de Louvain, Brussels, Belgium
F Vermeulen
*University Hospital of Leuven, Leuven, Belgium
M J Hug
++++Clinical Chemistry, Université Catholique de Louvain, Brussels, Belgium
G Rault
ffffCentre de Référence et de Compétence de la Mucoviscidose, Centre de Perharidy, Roscoff, France
T Nguyen-Khoa
*****Depts of Biochemistry A and Paediatric Pulmonology, CRCM, Hôpital Necker-Enfants Malades AP-PH, Paris, France
C Barreto
#####Dept of Paediatrics, Hospital de Santa Maria, Lisbon, Portugal
M Proesmans
*University Hospital of Leuven, Leuven, Belgium
I Sermet-Gaudelus
¶¶¶¶¶Hôpital Necker- Enfants Malades, Université Paris Descartes, INSERM U 845, Paris, France
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Table of Contents
Cftr biomarkers: time for promotion to surrogate endpoint?
K. De Boeck, L Kent, J Davies, N Derichs, M Amaral, SM Rowe, P Middleton, H de Jonge, I Bronsveld, M Wilschanski, P Melotti, I Danner-Boucher, S Boerner, I Fajac, K Southern, RA de Nooijer, A Bot, Y de Rijke, E de Wachter, T Leal, F Vermeulen, M J Hug, G Rault, T Nguyen-Khoa, C Barreto, M Proesmans, I Sermet-Gaudelus
European Respiratory Journal Jan 2012, erj00575-2012; DOI: 10.1183/09031936.00057512
Cftr biomarkers: time for promotion to surrogate endpoint?
K. De Boeck, L Kent, J Davies, N Derichs, M Amaral, SM Rowe, P Middleton, H de Jonge, I Bronsveld, M Wilschanski, P Melotti, I Danner-Boucher, S Boerner, I Fajac, K Southern, RA de Nooijer, A Bot, Y de Rijke, E de Wachter, T Leal, F Vermeulen, M J Hug, G Rault, T Nguyen-Khoa, C Barreto, M Proesmans, I Sermet-Gaudelus
European Respiratory Journal Jan 2012, erj00575-2012; DOI: 10.1183/09031936.00057512