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Serum type I and type III procollagen peptide levels in sarcoidosis

L Bacchella, C Tinelli, LS Gile, V Peona, C Aprile, M Gorrini, L Pasturenzi, G Cetta, M Luisetti
European Respiratory Journal 1996 9: 1648-1651; DOI:
L Bacchella
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C Tinelli
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LS Gile
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V Peona
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C Aprile
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M Gorrini
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L Pasturenzi
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G Cetta
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M Luisetti
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Abstract

Type I and type III are the most abundant collagens in the lung. The aim of our study was to compare type I and III procollagen peptides in sera of sarcoid patients. Sixty eight patients with sarcoidosis were studied (19 with newly recognized disease, 7 with relapsing disease, 15 with chronic disease, and 27 in stable remission). Thirty healthy volunteers served as controls. The levels of procollagen I and III peptides were determined by radioimmunoassay. Angiotensin-converting enzyme (ACE) level was evaluated by means of a colorimetric assay. In patients with newly recognized sarcoidosis, both serum procollagen I and III peptide levels were increased with respect to controls (p=0.0014 and p<0.00001, respectively). There was a poor correlation between levels of procollagen I and III (r=0.26), whereas there was a closer correlation between procollagen III and ACE (r=0.69). Procollagen I peptide level did not identify patients in roentgenological stage III. In conclusion, in patients with newly recognized sarcoidosis there is a significant increase in the serum level of procollagen I peptide. However, procollagen I peptide is not a marker of sarcoid patients with fibrosis, ie. stage III disease. Its clinical usefulness seems to be weaker than that of procollagen III peptide.

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Serum type I and type III procollagen peptide levels in sarcoidosis
L Bacchella, C Tinelli, LS Gile, V Peona, C Aprile, M Gorrini, L Pasturenzi, G Cetta, M Luisetti
European Respiratory Journal Aug 1996, 9 (8) 1648-1651;

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Serum type I and type III procollagen peptide levels in sarcoidosis
L Bacchella, C Tinelli, LS Gile, V Peona, C Aprile, M Gorrini, L Pasturenzi, G Cetta, M Luisetti
European Respiratory Journal Aug 1996, 9 (8) 1648-1651;
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