Extract
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease (ILD), characterised by progressive scarring and distortion of the lung architecture that finally leads to respiratory failure [1, 2]. Although the initial cause of IPF remains unknown, some pathogenic pathways have been identified in the past two decades, which have represented the basis for emerging anti-fibrotic drugs [3]. Furthermore, risk factors for developing the disease and contributing to fibrotic progression have been identified and validated, including genetic mutations, inhaled exposures and gastro-oesophageal reflux disease (GORD) [1–3].
Abstract
Higher risk of IPF in the presence of a genetic predisposition to GORD increases the evidence for this causal relationship. Many other factors are involved in this complex story, which will be understood through the integration of different variables. https://bit.ly/3LbiPga
Footnotes
Conflict of interest: M. Molina-Molina reports grant support from Instituto de Salud Carlos III: Medicina Personalizada de Precisión (PMP22/00083) and Proyecto Estratégico para la Recuperación y Transformación Económica (PERTE).
Support statement: The author receives support from the Instituto de Salud Carlos III (ISCIII) through the grant of Medicina Personalizada de Precisión (PMP22/00083) and Proyecto Estratégico para la Recuperación y Transformación Económica (PERTE). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received April 2, 2023.
- Accepted April 18, 2023.
- Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org
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