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Table of Contents

01 April 2023; volume 61, issue 4

Podcast

  • You have accessRestricted access
    April Podcast: Global Initiative for Chronic Obstructive Lung Disease 2023 Report
    European Respiratory Journal 61 (4) 23E6104; DOI: 10.1183/13993003.E6104-2023 Published 2 May 2023

Editorials

  • Open Access
    New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic
    Anne C. Teirlinck, Caroline K. Johannesen, Eeva K. Broberg, Pasi Penttinen, Harry Campbell, Harish Nair, Rachel M. Reeves, Håkon Bøås, Mia Brytting, Wei Cai, AnnaSara Carnahan, Jean-Sebastien Casalegno, Kostas Danis, Cillian De Gascun, Joanna Ellis, Hanne-Dorthe Emborg, Manuel Gijon, Raquel Guiomar, Siddhivinayak S. Hirve, Helena Jiřincová, Hanna Nohynek, Jesus Angel Oliva, Richard Osei-Yeboah, John Paget, Gatis Pakarna, Richard Pebody, Lance Presser, Marie Rapp, Janine Reiche, Ana Paula Rodrigues, Elina Seppälä, Maja Socan, Karol Szymanski, Ramona Trebbien, Jaromíra Večeřová, Sylvie van der Werf, Maria Zambon, Adam Meijer, Thea K. Fischer
    European Respiratory Journal 61 (4) 2201569; DOI: 10.1183/13993003.01569-2022 Published 3 April 2023
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    Pushing (for) GOLD
    Mark Dransfield, Ravi Kalhan, Daiana Stolz
    European Respiratory Journal 61 (4) 2300366; DOI: 10.1183/13993003.00366-2023 Published 1 April 2023
  • Open Access
    A patient-tailored approach for corticosteroid treatment in COVID-19: still not there yet
    Mattia Nigro, James D. Chalmers, Stefano Aliberti
    European Respiratory Journal 61 (4) 2300270; DOI: 10.1183/13993003.00270-2023 Published 20 April 2023
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    Panta rhei (Πάντα ῥεῖ), or everything flows with long COVID
    Joan B. Soriano, Jessica González, Antoni Torres
    European Respiratory Journal 61 (4) 2202490; DOI: 10.1183/13993003.02490-2022 Published 1 April 2023
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    Transmission of Mycobacterium avium complex in healthcare settings: from environment, person to person, or both?
    Charles L. Daley, Nabeeh Hasan
    European Respiratory Journal 61 (4) 2300308; DOI: 10.1183/13993003.00308-2023 Published 20 April 2023
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    Obstructive sleep apnoea, nocturnal hypoxaemia, and cognitive decline in elderly patients
    AbdelKebir Sabil, Frédéric Gagnadoux
    European Respiratory Journal 61 (4) 2300300; DOI: 10.1183/13993003.00300-2023 Published 27 April 2023
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    Another piece in the pirfenidone puzzle
    Mareike Lehmann, Martin Kolb
    European Respiratory Journal 61 (4) 2300240; DOI: 10.1183/13993003.00240-2023 Published 27 April 2023
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    The alternative approach: genomic classifiers for prognostication in interstitial lung disease
    Gillian C. Goobie, Sabina A. Guler
    European Respiratory Journal 61 (4) 2300033; DOI: 10.1183/13993003.00033-2023 Published 1 April 2023
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    The effects of elexacaftor/tezacaftor/ivacaftor beyond the epithelium: spurring macrophages to fight infections
    Emanuela M. Bruscia
    European Respiratory Journal 61 (4) 2300216; DOI: 10.1183/13993003.00216-2023 Published 1 April 2023
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    Lung volume reduction in COPD: scope or surgery
    Francesca Polverino, Frank Sciurba
    European Respiratory Journal 61 (4) 2300353; DOI: 10.1183/13993003.00353-2023 Published 27 April 2023
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    COPD pathophysiology: climbing the waterfall of cell death to find a target
    Didier Cataldo
    European Respiratory Journal 61 (4) 2300093; DOI: 10.1183/13993003.00093-2023 Published 1 April 2023
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    Defining the questions to be asked in severe asthma trials: data from the COMSA working group
    Thomas Eiwegger, Sarah A. Bendien
    European Respiratory Journal 61 (4) 2202058; DOI: 10.1183/13993003.02058-2022 Published 3 April 2023
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    Core outcome sets, developed collaboratively with patients, can improve the relevance and comparability of clinical trials
    Alexander G. Mathioudakis, Ekaterina Khaleva, Markus Fally, Paula R. Williamson, Jens-Ulrik Jensen, Tim W. Felton, Chris Brightling, Andrew Bush, Tonya Winders, John Linnell, Valeria Ramiconi, Courtney Coleman, Tobias Welte, Graham Roberts, Jørgen Vestbo
    European Respiratory Journal 61 (4) 2202107; DOI: 10.1183/13993003.02107-2022 Published 3 April 2023
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    ERJ advances: state of the art in definitions and diagnosis of COPD
    Sachin Ananth, John R. Hurst
    European Respiratory Journal 61 (4) 2202318; DOI: 10.1183/13993003.02318-2022 Published 20 April 2023

Task Force Report

  • GOLD executive summary

    • Open Access
      Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
      Alvar Agustí, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, M. Victorina López Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
      European Respiratory Journal 61 (4) 2300239; DOI: 10.1183/13993003.00239-2023 Published 1 April 2023

ERS Official Documents

  • ERS/ESICM/ESCMID/ALAT guidelines

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      ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
      Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, Stefano Aliberti, Massimo Antonelli, Matteo Bassetti, Lieuwe Bos, James D. Chalmers, Lennie Derde, Jan de Waele, Jose Garnacho-Montero, Marin Kollef, Carlos Luna, Rosario Menendez, Michael Niederman, Dmitry Ponomarev, Marcos Restrepo, David Rigau, Marcus J. Schultz, Emmanuel Weiss, Tobias Welte, Richard Wunderink
      European Respiratory Journal 61 (4) 2200735; DOI: 10.1183/13993003.00735-2022 Published 3 April 2023
  • ERS technical standards

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      Nasal nitric oxide measurement in children for the diagnosis of primary ciliary dyskinesia: European Respiratory Society technical standard
      Nicole Beydon, Panayiotis Kouis, June K. Marthin, Philipp Latzin, Murielle Colas, Stephanie D. Davis, Eric Haarman, Amanda Lea Harris, Claire Hogg, Emma Kilbride, Claudia E. Kuehni, Diana Marangu, Kim G. Nielsen, Catherine Pendergrast, Phil Robinson, Nisreen Rumman, Matthew Rutter, Woolf T. Walker, Thomas Ferkol, Jane S. Lucas
      European Respiratory Journal 61 (4) 2202031; DOI: 10.1183/13993003.02031-2022 Published 20 April 2023

Original Research Articles

  • COVID-19

    • Open Access
      Prolonged higher dose methylprednisolone versus conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)
      Francesco Salton, Paola Confalonieri, Stefano Centanni, Michele Mondoni, Nicola Petrosillo, Paolo Bonfanti, Giuseppe Lapadula, Donato Lacedonia, Antonio Voza, Nicoletta Carpenè, Marcella Montico, Nicolò Reccardini, Gianfranco Umberto Meduri, Barbara Ruaro, MEDEAS Collaborative Group, Marco Confalonieri, the MEDEAS Collaborative Group , Gloria Maria Citton, Giulia Lapadula, Chiara Bozzi, Stefano Tavano, Riccardo Pozzan, Alessia Giovanna Andrisano, Mohamad Jaber, Marco Mari, Liliana Trotta, Lucrezia Mondini, Mariangela Barbieri, Luca Ruggero, Caterina Antonaglia, Sara Soave, Chiara Torregiani, Tjaša Bogatec, Andrea Baccelli, Giulia Nalesso, Beatrice Re, Stefano Pavesi, Maria Pia Foschino Barbaro, Antonella Giuliani, Claudia Ravaglia, Venerino Poletti, Raffaele Scala, Luca Guidelli, Nicoletta Golfi, Andrea Vianello, Alessia Achille, Paolo Lucernoni, Anna Talia Gaccione, Micaela Romagnoli, Alessia Fraccaro, Nicola Malacchini, Mario Malerba, Beatrice Ragnoli, Alessandro Sanduzzi Zamparelli, Marialuisa Bocchino, Francesco Blasi, Maura Spotti, Carmen Miele, Federica Piedepalumbo, Ivan Barone, Stefano Baglioni, Meridiana Dodaj, Cosimo Franco, Francesco Andrani, Angelo Mangia, Annalisa Mancini, Laura Carrozzi, Annalisa Rafanelli, Elisabetta Casto, Paola Rogliani, Josuel Ora, Giovanna Elisiana Carpagnano, Valentina Di Lecce, Mario Tamburrini, Alberto Papi, Marco Contoli, Roberto Luzzati, Marta Zatta, Stefano Di Bella, Emanuela Caraffa, Daniela Francisci, Andrea Tosti, Carlo Pallotto, Francesco Giuseppe De Rosa, Alessio Pecori, Marta Franceschini, Massimiliano Carlin, Valentina Orsini, Anna Spolti, Marta Inannace, Teresa Santantonio, Rossella Meli, Sara Sauro, Carlo Fedeli, Elisabetta Mangini, Gianni Biolo, Alessio Nunnari, Antonello Pietrangelo, Elena Corradini, Davide Bocchi, Chiara Boarini, Antonella Zucchetto, Simone Lanini
      European Respiratory Journal 61 (4) 2201514; DOI: 10.1183/13993003.01514-2022 Published 20 April 2023
    • Open Access
      Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study
      Frédéric Schlemmer, Simon Valentin, Laurent Boyer, Anne Guillaumot, François Chabot, Clairelyne Dupin, Pierre Le Guen, Gwenael Lorillon, Anne Bergeron, Damien Basille, Julia Delomez, Claire Andrejak, Valentine Bonnefoy, Hélène Goussault, Jean-Baptiste Assié, Pascaline Choinier, Anne-Marie Ruppert, Jacques Cadranel, Maria Chiara Mennitti, Mehdi Roumila, Charlotte Colin, Sven Günther, Olivier Sanchez, Thomas Gille, Lucile Sésé, Yurdagul Uzunhan, Morgane Faure, Maxime Patout, Capucine Morelot-Panzini, Pierantonio Laveneziana, Maeva Zysman, Elodie Blanchard, Chantal Raherison-Semjen, Violaine Giraud, Etienne Giroux-Leprieur, Stéfanie Habib, Nicolas Roche, Anh Tuan Dinh-Xuan, Islem Sifaoui, Pierre-Yves Brillet, Camille Jung, Emmanuelle Boutin, Richard Layese, Florence Canoui-Poitrine, Bernard Maitre on behalf of the RE2COVERI Study Group
      European Respiratory Journal 61 (4) 2201532; DOI: 10.1183/13993003.01532-2022 Published 1 April 2023
  • Respiratory infections

    • Open Access
      Mycobacterium avium complex genomics and transmission in a London hospital
      Andries J. van Tonder, Huw C. Ellis, Colin P. Churchward, Kartik Kumar, Newara Ramadan, Susan Benson, Julian Parkhill, Miriam F. Moffatt, Michael R. Loebinger, William O.C. Cookson
      European Respiratory Journal 61 (4) 2201237; DOI: 10.1183/13993003.01237-2022 Published 20 April 2023
  • Sleep

    • Open Access
      Obstructive sleep apnoea and 5-year cognitive decline in the elderly
      Nicola Andrea Marchi, Geoffroy Solelhac, Mathieu Berger, José Haba-Rubio, Nadia Gosselin, Peter Vollenweider, Pedro Marques-Vidal, Julius Popp, Armin von Gunten, Martin Preisig, Bogdan Draganski, Raphael Heinzer
      European Respiratory Journal 61 (4) 2201621; DOI: 10.1183/13993003.01621-2022 Published 27 April 2023
  • Interstitial lung disease

    • Open Access
      Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone
      Hsiao-Yen Ma, Jason A. Vander Heiden, Salil Uttarwar, Ying Xi, Elsa-Noah N'Diaye, Ryan LaCanna, Patrick Caplazi, Sarah Gierke, John Moffat, Paul J. Wolters, Ning Ding
      European Respiratory Journal 61 (4) 2200604; DOI: 10.1183/13993003.00604-2022 Published 27 April 2023
    • You have accessRestricted access
      Interstitial lung disease progression after genomic usual interstitial pneumonia testing
      Sachin Chaudhary, S. Sam Weigt, Manuel L. Ribeiro Neto, Bryan S. Benn, Janelle Vu Pugashetti, Rebecca Keith, Arista Chand, Scott Oh, Fayez Kheir, Vijaya Ramalingam, Joshua J. Solomon, Richart Harper, Joseph A. Lasky, Justin M. Oldham
      European Respiratory Journal 61 (4) 2201245; DOI: 10.1183/13993003.01245-2022 Published 1 April 2023
  • Cystic fibrosis

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      Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor
      Shuzhong Zhang, Chandra L. Shrestha, Frank Robledo-Avila, Devi Jaganathan, Benjamin L. Wisniewski, Nevian Brown, Hanh Pham, Katherine Carey, Amal O. Amer, Luanne Hall-Stoodley, Karen S. McCoy, Shasha Bai, Santiago Partida-Sanchez, Benjamin T. Kopp
      European Respiratory Journal 61 (4) 2102861; DOI: 10.1183/13993003.02861-2021 Published 1 April 2023
    • Open Access
      Elexacaftor/tezacaftor/ivacaftor corrects monocyte microbicidal deficiency in cystic fibrosis
      Luca Cavinato, Francesco R. Luly, Valentina Pastore, Daniele Chiappetta, Gloria Sangiorgi, Eva Ferrara, Pia Baiocchi, Giuseppe Mandarello, Giuseppe Cimino, Paola Del Porto, Fiorentina Ascenzioni
      European Respiratory Journal 61 (4) 2200725; DOI: 10.1183/13993003.00725-2022 Published 1 April 2023
  • COPD

    • Open Access
      Lung volume reduction surgery versus endobronchial valves: a randomised controlled trial
      Sara C. Buttery, Winston Banya, Rocco Bilancia, Elizabeth Boyd, Julie Buckley, Neil J. Greening, Kay Housley, Simon Jordan, Samuel V. Kemp, Alan J.B. Kirk, Lorna Latimer, Kelvin Lau, Rod Lawson, Adam Lewis, John Moxham, Sridhar Rathinam, Michael C. Steiner, Sara Tenconi, David Waller, Pallav L. Shah, Nicholas S. Hopkinson on behalf of the CELEB investigators
      European Respiratory Journal 61 (4) 2202063; DOI: 10.1183/13993003.02063-2022 Published 27 April 2023
  • Translational science and COPD

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      RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
      Hannelore P. Van Eeckhoutte, Chantal Donovan, Richard Y. Kim, Thomas M. Conlon, Meshal Ansari, Haroon Khan, Ranjith Jayaraman, Nicole G. Hansbro, Yves Dondelinger, Tom Delanghe, Allison M. Beal, Brad Geddes, John Bertin, Tom Vanden Berghe, Joyceline De Volder, Tania Maes, Peter Vandenabeele, Bart M. Vanaudenaerde, Dieter Deforce, Sonja Škevin, Filip Van Nieuwerburgh, Fien M. Verhamme, Guy F. Joos, Sobia Idrees, Herbert B. Schiller, Ali Önder Yildirim, Alen Faiz, Mathieu J.M. Bertrand, Guy G. Brusselle, Philip M. Hansbro, Ken R. Bracke
      European Respiratory Journal 61 (4) 2201506; DOI: 10.1183/13993003.01506-2022 Published 1 April 2023

Reviews

  • Open Access
    Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
    Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Apostolos Bossios, Arnaud Bourdin, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Sven-Erik Dahlén, Ratko Djukanovic, Antoine Deschildre, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Simone Hashimoto, Gunilla Hedlin, Gerard H. Koppelman, Erik Melén, Clare S. Murray, Charles Pilette, Celeste Porsbjerg, Katharine C. Pike, Franca Rusconi, Clare Williams, Birgit Ahrens, Peter Alter, Freja Anckers, Maarten van den Berge, Katharina Blumchen, Guy Brusselle, Graham W. Clarke, Danen Cunoosamy, Barbro Dahlén, Piers Dixey, Andrew Exley, Urs Frey, Erol A. Gaillard, Lisa Giovannini-Chami, Jonathan Grigg, Diana Hartenstein, Liam G. Heaney, Bülent Karadag, Susanne Kaul, Inger Kull, Amelia Licari, Anke H. Maitland-van der Zee, Vera Mahler, Ann-Marie M. Schoos, Prasad Nagakumar, Jenny Negus, Hanna Nielsen, James Paton, Mariëlle Pijnenburg, Valeria Ramiconi, Sofia Romagosa Vilarnau, Stefania Principe, Niels Rutjes, Sejal Saglani, Paul Seddon, Florian Singer, Heribert Staudinger, Steve Turner, Susanne Vijverberg, Tonya Winders, Valentyna Yasinska, Graham Roberts on behalf of the COMSA Working Group in the 3TR Consortium
    European Respiratory Journal 61 (4) 2200606; DOI: 10.1183/13993003.00606-2022 Published 3 April 2023
  • You have accessRestricted access
    Identifying and appraising outcome measures for severe asthma: a systematic review
    Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlén, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melén, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts on behalf of the 3TR Consortium Respiratory Work Package
    European Respiratory Journal 61 (4) 2201231; DOI: 10.1183/13993003.01231-2022 Published 3 April 2023
  • Open Access
    Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond
    Marcus A. Mall, Gerard J. Criner, Marc Miravitlles, Steven M. Rowe, Claus F. Vogelmeier, David J. Rowlands, Matthias Schoenberger, Pablo Altman
    European Respiratory Journal 61 (4) 2201307; DOI: 10.1183/13993003.01307-2022 Published 1 April 2023

State of the Art

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    Idiopathic pulmonary fibrosis: state of the art for 2023
    Anna J. Podolanczuk, Carey C. Thomson, Martine Remy-Jardin, Luca Richeldi, Fernando J. Martinez, Martin Kolb, Ganesh Raghu
    European Respiratory Journal 61 (4) 2200957; DOI: 10.1183/13993003.00957-2022 Published 20 April 2023

Research letters

  • Open Access
    Trends in COVID-19-associated mortality in patients with pulmonary hypertension: a COMPERA analysis
    Kai-Helge Schmidt, Katrin Milger, Christine Pausch, Doerte Huscher, David Pittrow, Ekkehard Grünig, Gerd Staehler, Henning Gall, Oliver Distler, Dirk Skowasch, Michael Halank, Heinrike Wilkens, Matthias Held, Hans Klose, Marius M. Hoeper
    European Respiratory Journal 61 (4) 2202440; DOI: 10.1183/13993003.02440-2022 Published 27 April 2023
  • Open Access
    Chronic thromboembolic pulmonary hypertension and clot resolution after COVID-19-associated pulmonary embolism
    Cindy M.M. de Jong, Chantal Visser, Remy H.H. Bemelmans, Wim G. Boersma, Bram van den Borst, J. Louise I. Burggraaf, Suzanne C. Cannegieter, Arina J. ten Cate-Hoek, F. Nanne Croles, Harald J. Faber, Laura M. Faber, Merel E. Hellemons, Lisa M. Hessels, Menno V. Huisman, Pieter W. Kamphuisen, Stephanie C.E. Koster, Lucia J.M. Kroft, Ivo van der Lee, Jenneke Leentjens, Karina Meijer, Maarten K. Ninaber, Brigitte M. Sondermeijer, Susanne Stads, Anton Vonk Noordegraaf, Kristien Winckers, Marieke J.H.A. Kruip, Frederikus A. Klok on behalf of the Dutch COVID & Thrombosis Coalition investigators
    European Respiratory Journal 61 (4) 2300171; DOI: 10.1183/13993003.00171-2023 Published 20 April 2023

Correspondence

  • You have accessRestricted access
    Muscle sympathetic nerve activity and adaptive servo-ventilation: questions remain
    Dany Jaffuel, Jean Pierre Mallet, François Roubille, Arnaud Bourdin
    European Respiratory Journal 61 (4) 2300002; DOI: 10.1183/13993003.00002-2023 Published 20 April 2023
  • You have accessRestricted access
    Reply to: Muscle sympathetic nerve activity and adaptive servo-ventilation: questions remain
    Renaud Tamisier, Jean-Louis Pépin, Patrick Lévy
    European Respiratory Journal 61 (4) 2300247; DOI: 10.1183/13993003.00247-2023 Published 20 April 2023
  • You have accessRestricted access
    What could explain the high prevalence of progressive fibrosing interstitial lung disease in a patient registry?
    Onofre Moran-Mendoza, Ahmad Al-Jarallah, Salem Alqahtani, Carla Paredes
    European Respiratory Journal 61 (4) 2300019; DOI: 10.1183/13993003.00019-2023 Published 1 April 2023
  • You have accessRestricted access
    Design considerations and implications of findings on progressive pulmonary fibrosis from the prospective Canadian Registry for Pulmonary Fibrosis
    Christopher J. Ryerson, Nathan Hambly, Martin Kolb
    European Respiratory Journal 61 (4) 2300208; DOI: 10.1183/13993003.00208-2023 Published 1 April 2023

Author Correction

  • You have accessRestricted access
    “Gut microbiota mediate vascular dysfunction in a murine model of sleep apnoea: effect of probiotics.” M. Badran, A. Khalyfa, A.C. Ericsson, C. Puech, Z. McAdams, S.B. Bender and D. Gozal. Eur Respir J 2023; 61: 2200002.
    European Respiratory Journal 61 (4) 2250002; DOI: 10.1183/13993003.50002-2022 Published 27 April 2023
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