Extract
Obstructive sleep apnoea (OSA) in children, with a prevalence of 1–5.7% [1], is one of the most common causes of sleep disordered breathing in children, with a peak of occurrence at 2–8 years old [2]. Paediatric sleep apnoea is typically associated with snoring, indicating the presence of increased upper airway resistance. The most common factor underlying the presence of paediatric sleep apnoea is hypertrophy of the upper airway lymphadenoid tissues, which results in increased upper airway collapsibility. Moreover, obesity, neurological or neuromuscular diseases, and gastro-oesophageal reflux are some risk factors that frequently occur in paediatric sleep apnoea.
Abstract
Single-cell sequencing emerges as a platform to observe and characterise relevant morbidity-related pathophysiologic mechanisms associated with paediatric OSA https://bit.ly/3jroqVo
Footnotes
Conflict of interest: All authors have nothing to disclose.
Support statement: This work was supported by Instituto de Salud Carlos III (ISCIII) (PI10/02763, PI10/02745, PI18/00449, PI21/00337), co-funded by FEDER, “Una manera de hacer europa”. M. Sánchez-de-la-Torre has received financial support from a “Ramón y Cajal” grant (RYC2019-027831-I) from the “Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación” co-funded by the European Social Fund (ESF)/“Investing in your future”. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received December 2, 2022.
- Accepted December 16, 2022.
- Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org