Extract
Heart failure (HF) due to left ventricular systolic dysfunction is characterised by numerous neuro-hormonal alterations, a prominent feature of which is activation of the sympathetic nervous system. The pathogenesis of sympatho-excitation in HF, albeit yet to be fully elucidated, is multifactorial, including blunted cardiopulmonary inhibition, arterial baroreceptor desensitisation, exacerbated muscle mechanoreceptor control, chemoreflex dysfunction, augmented cardiac reflex sympatho-excitation, and the influences of abnormal humoral and metabolic products within the central nervous system [1].
Abstract
This sub-study of the SERVE-HF study found unchanged peripheral nervous sympathetic activity (MSNA) in heart failure patients on medical treatment or on ASV after 12 weeks. Reduced MSNA was associated with worse prognosis only in the ASV group. http://bit.ly/3i5WRRb
Footnotes
Conflict of interest: M.R. Bonsignore reports lecture honoraria from Bioprojet and Jazz Pharmaceuticals; advisory board membership at Bioprojet; outside the submitted work. M.T. La Rovere has nothing to disclose.
- Received November 11, 2022.
- Accepted November 12, 2022.
- Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org
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