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Insights into the clinical outcomes of bronchiectasis

Zhen-feng He, Shan-shan Zha, Cui-xia Pan, Nan-shan Zhong, Wei-jie Guan
European Respiratory Journal 2023 61: 2202104; DOI: 10.1183/13993003.02104-2022
Zhen-feng He
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
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Shan-shan Zha
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
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Cui-xia Pan
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
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Nan-shan Zhong
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
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Wei-jie Guan
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
2Department of Thoracic Surgery, Guangzhou Institute for Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
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We read with great interest the article by Dhar et al. [1] which, based on data from EMBARC/Respiratory Research Network, thoroughly investigated the clinical outcomes of bronchiectasis in India. The authors have identified important predictors of poor clinical outcomes, some of which represented critical therapeutic targets because these may represent treatable or preventable traits. For instance, identification of the frequent exacerbators who would benefit from intensified airway clearance, macrolide therapy and pulmonary rehabilitation may result in an improved clinical outcome. Their work may also shed light on refining the management strategy for patients with bronchiectasis in many low- and middle-income countries globally. In spite of these promising findings, there are some concerns that merit further discussion.

Abstract

There are queries regarding data from EMBARC-India due to an imbalance of patient baseline characteristics, confounded by different clinical statuses, other co-existing chronic respiratory diseases and the rate of inhaled corticosteroid use http://bit.ly/3X3CxzN

Footnotes

  • Conflict of interest: The authors declared no conflict of interest with any financial organisation regarding the material discussed in the manuscript.

  • Support statement: This work was primarily supported by the National Natural Science Foundation – Outstanding Youth Fund (number 82222001), National Natural Science Foundation (number 81870003), Guangdong Natural Science Foundation (number 2019A1515011634), and Zhongnanshan Medical Foundation of Guangdong Province (number ZNSA-2020013) (to Wei-jie Guan).

  • Received November 1, 2022.
  • Accepted November 12, 2022.
  • Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org
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Insights into the clinical outcomes of bronchiectasis
Zhen-feng He, Shan-shan Zha, Cui-xia Pan, Nan-shan Zhong, Wei-jie Guan
European Respiratory Journal Feb 2023, 61 (2) 2202104; DOI: 10.1183/13993003.02104-2022

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Insights into the clinical outcomes of bronchiectasis
Zhen-feng He, Shan-shan Zha, Cui-xia Pan, Nan-shan Zhong, Wei-jie Guan
European Respiratory Journal Feb 2023, 61 (2) 2202104; DOI: 10.1183/13993003.02104-2022
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