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Limited interstitial abnormalities on CT associated with hiatus hernia: a pathogenetic pathway versus an epiphenomenon linked to biologic senescence

Peter M. George, Athol U. Wells
European Respiratory Journal 2023 61: 2201900; DOI: 10.1183/13993003.01900-2022
Peter M. George
1Department of Interstitial Lung Disease, Royal Brompton Hospital, London, UK
2National Heart and Lung Institute, Imperial College London, London, UK
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Athol U. Wells
1Department of Interstitial Lung Disease, Royal Brompton Hospital, London, UK
2National Heart and Lung Institute, Imperial College London, London, UK
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  • For correspondence: rbhild@rbht.nhs.uk
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Extract

The proposed relationship between hiatus hernia and pulmonary fibrosis has long been recognised. In 1976, Mays et al. [1] explored the prevalence of hiatus hernia in patients with pulmonary fibrosis classified as “idiopathic”, “immune mediated” and “known aetiology”. In all three groups the prevalence of hiatus hernia and acid reflux was higher than a matched population, but the rates were strikingly highest in the group with idiopathic interstitial pulmonary fibrosis, in which 41 of 48 patients (85%) had a hiatus hernia. Fast forward 40 years, and the association between hiatus hernia and pulmonary fibrosis is gaining traction. In patients with idiopathic pulmonary fibrosis (IPF), Noth et al. [2]. established a hiatus hernia prevalence on thoracic computed tomography (CT) scans of 39%, Tossier et al. [3] a prevalence of 53% and Mackintosh et al. [4] a prevalence of 42%.

Abstract

Does hiatus hernia play a role in the development of early ILD? Read on to try and unravel the supportive evidence from the potential confounders. https://bit.ly/3iS4DOF

Footnotes

  • Conflicts of interest: A.U. Wells reports consulting fees and lecture honoraria from Boehringer Ingelheim and Roche, travel support from Boehringer Ingelheim, and is President Elect of WASOG, outside the submitted work. P.M. George reports grants from Boehringer Ingelheim, lecture honoraria and fees from Boehringer Ingelheim, Roche, Teva, Cipla and Brainomix, and travel support from Boehringer Ingelheim and Roche, outside the submitted work.

  • Received September 30, 2022.
  • Accepted December 8, 2022.
  • Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org
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Limited interstitial abnormalities on CT associated with hiatus hernia: a pathogenetic pathway versus an epiphenomenon linked to biologic senescence
Peter M. George, Athol U. Wells
European Respiratory Journal Jan 2023, 61 (1) 2201900; DOI: 10.1183/13993003.01900-2022

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Limited interstitial abnormalities on CT associated with hiatus hernia: a pathogenetic pathway versus an epiphenomenon linked to biologic senescence
Peter M. George, Athol U. Wells
European Respiratory Journal Jan 2023, 61 (1) 2201900; DOI: 10.1183/13993003.01900-2022
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