Abstract
Despite being the golden standard to diagnose and classify airway diseases, the sensitivity of spirometry to detect early airway impairment can be questioned (Wouters et al, JCM 2021). The current study aims to investigate the association between abnormal oscillometry values and the presence of respiratory symptoms in subjects with normal spirometry.
5646 adults (18-90 years) from the Austrian LEAD general population cohort with normal spirometry (FEV1/FVC and FVC) were included. For each subject, within-breath oscillometry (RESMON PRO FULL, RESTECH Srl, Italy), spirometry, respiratory symptoms, and/or respiratory diseases were recorded on the same day. Abnormal FOT was defined according to Oostveen et al., ERJ 2013.
We computed the risk ratios of presenting symptoms and/or diseases for subjects with 1) an abnormal oscillometry parameter (n=785), 2) abnormal resistance (Rrs; n=541), 3) abnormal reactance (Xrs; n=481)), 4) abnormal inspiratory parameters (n=351), and 5) abnormal expiratory parameters (n=667).
Changes in FOT parameters are highly prevalent in subjects with normal spirometry and are consistently related to reported respiratory symptoms and past or present respiratory diseases (Figure).
FOT is a simple, feasible and sensitive method to objectify respiratory conditions in normal spirometry.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 4465.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2022
