Abstract
Background: Sarcopenia is a prognostic indicator in COPD and IPF. Identification of sarcopenic patients may enable intervention to improve prognosis. Interstitial lung disease (ILD) is the most common non-musculoskeletal manifestation of patients with Idiopathic Inflammatory Myopathies (IIMs). This study investigated muscle mass in IIM, and its relationship to ILD disease severity.
Methods: A retrospective review of 31 patients undergoing treatment at a single institution from 2015–2021 was performed. CT scans at diagnosis and on clinical follow up underwent morphomic analysis using CoreSlicer, a web-based tool which enables semi-automated segmentation of muscle and fat. Bilateral Erector Spinae Muscle (ESM) and Pectoralis Muscle (PM) cross-sectional areas (CSA) were calculated. All morphomic data were correlated with lung function including forced vital capacity (FVC) and biochemical markers.
Results: Data from 31 patients (16 male, mean age 69.8 years) were analysed. No relationship was established between change in morphomics between sequential CT scans and change in PFTs over the same interval.
Therre were significant correlations between baseline and follow-up PM CSA, ESM CSA and FVC when treated as separate data points. A negative relationship between the patients’ albumin levels and their visceral fat at T12 was also found (see Table 1).
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 4160.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2022
