Abstract
Background: Expiratory flow limitation (EFL) has been associated in previous studies with the within-breathe difference in respiratory reactance (ΔX5) measured by Forced Oscillation Technique (FOT), predominantly in COPD.
Aim: To evaluate whether EFL measured by FOT in patients with obstructive lung diseases is correlated to symptoms and quality of life questionnaires.
Methods: Within-breathe difference (expiratory-inspiratory) resistance (ΔR5, ΔR19) and reactance (ΔΧ5) were used as a measure of EFL and were evaluated by FOT using Resmon Pro in a total of 452 subjects (101 COPD, 321 asthma, 30 healthy smokers). Symptom and quality of life (QoL) questionnaires were completed, CAT and CCQ by COPD patients and healthy smokers, and ACT, ACQ, AQLQ by asthmatics.
Results: ΔX5 correlated with symptoms in both COPD (r=-0.317; p=0.01) and asthma patients (r=0.2; p<0.001) but not in healthy smokers. In addition, ΔX5 correlated with QoL measured by CCQ (r=-0.42; p=0.001) in COPD, but not with AQLQ in asthma. Within-breathe difference in respiratory resistance, ΔR5 correlated weakly with ACQ (r=0.13; p=0.028) and showed a tendency with ACT (r=-0.11; p=0.055) in asthma, while ΔR19 did not correlate with neither symptoms nor QoL.
Conclusion: Within-breathe respiratory reactance (ΔX5) correlated best with symptoms and quality of life questionnaires in COPD and partially in asthmatics. On the other hand, respiratory resistance was associated with symptoms in asthma.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 4010.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2022
